The goal of the Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decision-making and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.

Public Health Relevance

Gene-environment interactions are increasingly being recognized as having significant public health implications. HCRA will provide practical and timely information to technical and non-technical stakeholders on the results of the research, and the implications for the general public.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-LWJ-M)
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Harvard University
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Kappil, Maya; Wright, Robert O; Sanders, Alison P (2016) Developmental Origins of Common Disease: Epigenetic Contributions to Obesity. Annu Rev Genomics Hum Genet 17:177-92
Wagner, Peter J; Park, Hae-Ryung; Wang, Zhaoxi et al. (2016) In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Upregulated Genes and Cognitive Scores in Children. Environ Health Perspect :
Gleason, Kelsey M; Valeri, Linda; Shankar, A H et al. (2016) Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environ Health 15:103
Lin, Xinyi; Lee, Seunggeun; Wu, Michael C et al. (2016) Test for rare variants by environment interactions in sequencing association studies. Biometrics 72:156-64
Stroustrup, Annemarie; Hsu, Hsiao-Hsien; Svensson, Katherine et al. (2016) Toddler temperament and prenatal exposure to lead and maternal depression. Environ Health 15:71
Kile, Molly L; Cardenas, Andres; Rodrigues, Ema et al. (2016) Estimating Effects of Arsenic Exposure During Pregnancy on Perinatal Outcomes in a Bangladeshi Cohort. Epidemiology 27:173-81
Yung, Godwin; Lin, Xihong (2016) Validity of using ad hoc methods to analyze secondary traits in case-control association studies. Genet Epidemiol 40:732-743
Kile, Molly L; Faraj, Joycelyn M; Ronnenberg, Alayne G et al. (2016) A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women. BMC Public Health 16:158
Rodrigues, Ema G; Bellinger, David C; Valeri, Linda et al. (2016) Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 15:44
Tamayo Y Ortiz, Marcela; Téllez-Rojo, Martha María; Wright, Rosalind J et al. (2016) Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12-24 month-old infants from Mexico City. Environ Health 15:41

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