The goal of the Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decision-making and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.

Public Health Relevance

Gene-environment interactions are increasingly being recognized as having significant public health implications. HCRA will provide practical and timely information to technical and non-technical stakeholders on the results of the research, and the implications for the general public.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-LWJ-M)
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Harvard University
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Burris, Heather H; Baccarelli, Andrea A; Motta, Valeria et al. (2014) Association between length of gestation and cervical DNA methylation of PTGER2 and LINE 1-HS. Epigenetics 9:1083-91
Kile, Molly L; Rodrigues, Ema G; Mazumdar, Maitreyi et al. (2014) A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health 13:29
Claus Henn, Birgit; Coull, Brent A; Wright, Robert O (2014) Chemical mixtures and children's health. Curr Opin Pediatr 26:223-9
Kile, Molly L; Houseman, E Andres; Baccarelli, Andrea A et al. (2014) Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics 9:774-82
Gleason, Kelsey; Shine, James P; Shobnam, Nadia et al. (2014) Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health 2014:730636
Karwowski, Mateusz P; Just, Allan C; Bellinger, David C et al. (2014) Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study. Environ Health 13:77
Braun, Joseph M; Wright, Rosalind J; Just, Allan C et al. (2014) Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study. Environ Health 13:50
Fossati, Serena; Baccarelli, Andrea; Zanobetti, Antonella et al. (2014) Ambient particulate air pollution and microRNAs in elderly men. Epidemiology 25:68-78
Lee, Seunggeung; Abecasis, Gonçalo R; Boehnke, Michael et al. (2014) Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet 95:5-23
Orenstein, Sara T C; Thurston, Sally W; Bellinger, David C et al. (2014) Prenatal organochlorine and methylmercury exposure and memory and learning in school-age children in communities near the New Bedford Harbor Superfund site, Massachusetts. Environ Health Perspect 122:1253-9

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