The goal of the Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decision-making and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.
Gene-environment interactions are increasingly being recognized as having significant public health implications. HCRA will provide practical and timely information to technical and non-technical stakeholders on the results of the research, and the implications for the general public.
|Rosa-Parra, Jose A; Tamayo-Ortiz, Marcela; Lamadrid-Figueroa, Hector et al. (2018) Diurnal Cortisol Concentrations and Growth Indexes of 12- to 48-Month-Old Children From Mexico City. J Clin Endocrinol Metab 103:3386-3393|
|Lee, Jane J; Valeri, Linda; Kapur, Kush et al. (2018) Growth parameters at birth mediate the relationship between prenatal manganese exposure and cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. Int J Epidemiol 47:1169-1179|
|Sun, Ryan; Carroll, Raymond J; Christiani, David C et al. (2018) Testing for gene-environment interaction under exposure misspecification. Biometrics 74:653-662|
|Sun, Ryan; Wang, Zhaoxi; Claus Henn, Birgit et al. (2018) Identification of novel loci associated with infant cognitive ability. Mol Psychiatry :|
|Woo, May K; Young, Elisabeth S; Mostofa, Md Golam et al. (2018) Lead in Air in Bangladesh: Exposure in a Rural Community with Elevated Blood Lead Concentrations among Young Children. Int J Environ Res Public Health 15:|
|von Stackelberg, Katherine; Li, Miling; Sunderland, Elsie (2017) Results of a national survey of high-frequency fish consumers in the United States. Environ Res 158:126-136|
|Valeri, Linda; Mazumdar, Maitreyi M; Bobb, Jennifer F et al. (2017) The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect 125:067015|
|Claus Henn, Birgit; Bellinger, David C; Hopkins, Marianne R et al. (2017) Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site. Environ Health Perspect 125:067020|
|Tamayo Y Ortiz, Marcela; Téllez-Rojo, Martha María; Trejo-Valdivia, Belem et al. (2017) Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment. Environ Int 98:191-197|
|Lee, Jane J; Kapur, Kush; Rodrigues, Ema G et al. (2017) Anthropometric measures at birth and early childhood are associated with neurodevelopmental outcomes among Bangladeshi children aged 2-3years. Sci Total Environ 607-608:475-482|
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