The Research Translation Core (RTC) facilitates interaction within the SRP at OSU and serves as the SRP's main interface with our stakeholders, NIEHS, and other SRP Centers. The four main activities of the RTC include developing partnerships with government agencies, technology transfer, communicating within SRP, and disseminating information to a broad audience. The RTC has established relationships with regulatory enforcement and public health officials with interests in the Portland Harbor and Lower Duwamish Superfund Sites. In the next project period, the RTC will expand relationships to focus OSU SRP research on the assessment, monitoring and environmental health implications of PAHs and other contaminants found at Superfund sites throughout the United States. Technology transfer activities will include the use of PSDs for environmental monitoring at Superfund sites, and their potential applications in human health risk assessment. The RTC will collaborate and develop biological impact metrics which regulatory officials can use to monitor Superfund site remediation activities. We will promote the science of our biomedical projects to inform EPA and other risk assessors what our research findings imply for assessment of human health risks from PAH mixtures. The RTC will prepare educational materials and data resources relevant to current issues at Superfund Sites and disseminate information effectively to a broad audience. We will develop a new web-based search tool that provides comprehensive data about Superfund-related issues and sites throughout the United States. The RTC will facilitate communications within and outside the SRP, enhance opportunities for stakeholder interactions and impact, and report achievements to NIEHS and other SRP Centers. We will organize a seminar series that enhances trainee and center investigator awareness of Superfund site issues and emphasizes the impacts of OSU SRP research on decision-making. We plan to summarize the SRP'S translation achievements in a biannual electronic newsletter that we will distribute to other SRP programs, current and potential stakeholders, and NIEHS. The RTC will maintain a dynamic website providing updates on SRP activities, access to our seminar series, and profiles of our trainees.

Public Health Relevance

The specific aims of our Research Translation Core address cutting-edge issues relating to Superfund Sites throughout the United States. The work described within this proposal will advance the science of hazard assessment, environmental monitoring, and human health risk assessment for PAHs and other contaminants commonly found at Superfund Sites. The impact of our activities will inform and empower decision-makers in ways that reduce the public health impact of hazardous waste contaminants.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel ()
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon State University
United States
Zip Code
Garcia, Gloria R; Goodale, Britton C; Wiley, Michelle W et al. (2017) In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression. Mol Pharmacol 91:609-619
Donald, Carey E; Anderson, Kim A (2017) Assessing soil-air partitioning of PAHs and PCBs with a new fugacity passive sampler. Sci Total Environ 596-597:293-302
Wittwehr, Clemens; Aladjov, Hristo; Ankley, Gerald et al. (2017) How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology. Toxicol Sci 155:326-336
Madeen, Erin P; Williams, David E (2017) Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis. Rev Environ Health 32:73-81
Shrivastava, Manish; Lou, Silja; Zelenyuk, Alla et al. (2017) Global long-range transport and lung cancer risk from polycyclic aromatic hydrocarbons shielded by coatings of organic aerosol. Proc Natl Acad Sci U S A 114:1246-1251
Geier, Mitra C; Chlebowski, Anna C; Truong, Lisa et al. (2017) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol :
Knecht, Andrea L; Truong, Lisa; Simonich, Michael T et al. (2017) Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish. Neurotoxicol Teratol 59:27-34
Zhang, Guozhu; Truong, Lisa; Tanguay, Robert L et al. (2017) A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish. PLoS One 12:e0169408
Madeen, Erin P; Löhr, Christiane V; You, Hannah et al. (2017) Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog 56:163-171
Knecht, Andrea L; Truong, Lisa; Marvel, Skylar W et al. (2017) Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol 329:148-157

Showing the most recent 10 out of 156 publications