Preterm birth is a major health problem in the United States. In Puerto Rico, the preterm birth rate has increased to nearly 20% of live births and there is sufficient evidence that exposure to Superfund and related contaminants is a contributing factor. The theme of the PRoTECT Program is to use Puerto Rico as a testsite with dynamic exposure pathways through karstic aquifers to study Superfund and related contaminants and their contribution to preterm birth. The two goals of the Program are to: (1) Define the relationship between exposure to Superfund and related contaminants and preterm birth;and (2) Develop new technology for discovery, transport characterization, and green remediation of Superfund and related contaminants in karstic aquifers. To achieve these goals, the PRoTECT program will use a comprehensive, multidisciplinary approach that will ultimately lead to a better understanding of causal relationships between the exposures and preterm births, and will allow development of innovative remediation strategies to reduce short-term contaminant exposures, and long-term public health impacts. The five objectives of the Program are to: (1) Increase the evidence that Superfund and related contaminants contribute to preterm birth, identify the causative chemicals, and learn how to remediate these chemicals in karstic aquifers by a green process;(2) Build a better understanding of the potential role, mechanisms and relevance of pollution induced oxidative stress in preterm birth, (3) Discover and understand risk factors and their interactions for preterm birth by developing and mining an integrated, centralized, indexed data repository for Puerto Rico that includes epidemiological, hydrogeophysical, environmental fate and transport, and environmental exposure data, (4) Determine the effect of episodic transport on patterns of exposure through highly mobile karstic aquifers and develop adaptable remedial actions, and (5) Improve and apply nontargeted chemical analysis including bioassay-directed chemical analysis to biological samples and environmental samples. The PROTECT Program will conduct targeted and nontargeted studies to evaluate the contribution of exposure to Superfund and related contaminants to preterm birth. The targeted studies focus on chlorinated solvents and phthalates because they are suspect and model contaminants and because they are found in many Superfund sites in the US and Puerto Rico. The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors.
The Program will address the Healthy People 2010 objective to reduce preterm births to 7.6% from current preterm rates of 12.8% in the US and 19.7% in Puerto Rico in 2005. Program goals fit within Multi-Year Plans of the EPA's Office of Research and Development and also within the EPA's strategic plan for compliance and environmental stewardship that strives for green cleanup programs. The program will address many of the SBRP goals, including understanding the relationship between exposure and disease etiology, translating innovative remediation technologies, and improving the risk assessment decision-making process.
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|Ferguson, Kelly K; McElrath, Thomas F; Pace, Gerry G et al. (2017) Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women. Environ Sci Technol 51:4652-4660|
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|Wang, Poguang; Giese, Roger W (2017) Recommendations for quantitative analysis of small molecules by matrix-assisted laser desorption ionization mass spectrometry. J Chromatogr A 1486:35-41|
|Ferguson, Kelly K; Chen, Yin-Hsiu; VanderWeele, Tyler J et al. (2017) Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environ Health Perspect 125:488-494|
|Aung, Max T; Johns, Lauren E; Ferguson, Kelly K et al. (2017) Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environ Int 104:33-40|
|Yuan, Ye; Meeker, John D; Ferguson, Kelly K (2017) Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: The National Health and Nutrition Examination Survey 2003-2004. Sci Total Environ 575:400-405|
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