Preterm birth is a major health problem in the United States. In Puerto Rico, the preterm birth rate has increased to nearly 20% of live births and there is sufficient evidence that exposure to Superfund and related contaminants is a contributing factor. The theme of the PRoTECT Program is to use Puerto Rico as a testsite with dynamic exposure pathways through karstic aquifers to study Superfund and related contaminants and their contribution to preterm birth. The two goals of the Program are to: (1) Define the relationship between exposure to Superfund and related contaminants and preterm birth;and (2) Develop new technology for discovery, transport characterization, and green remediation of Superfund and related contaminants in karstic aquifers. To achieve these goals, the PRoTECT program will use a comprehensive, multidisciplinary approach that will ultimately lead to a better understanding of causal relationships between the exposures and preterm births, and will allow development of innovative remediation strategies to reduce short-term contaminant exposures, and long-term public health impacts. The five objectives of the Program are to: (1) Increase the evidence that Superfund and related contaminants contribute to preterm birth, identify the causative chemicals, and learn how to remediate these chemicals in karstic aquifers by a green process;(2) Build a better understanding of the potential role, mechanisms and relevance of pollution induced oxidative stress in preterm birth, (3) Discover and understand risk factors and their interactions for preterm birth by developing and mining an integrated, centralized, indexed data repository for Puerto Rico that includes epidemiological, hydrogeophysical, environmental fate and transport, and environmental exposure data, (4) Determine the effect of episodic transport on patterns of exposure through highly mobile karstic aquifers and develop adaptable remedial actions, and (5) Improve and apply nontargeted chemical analysis including bioassay-directed chemical analysis to biological samples and environmental samples. The PROTECT Program will conduct targeted and nontargeted studies to evaluate the contribution of exposure to Superfund and related contaminants to preterm birth. The targeted studies focus on chlorinated solvents and phthalates because they are suspect and model contaminants and because they are found in many Superfund sites in the US and Puerto Rico. The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors.

Public Health Relevance

The Program will address the Healthy People 2010 objective to reduce preterm births to 7.6% from current preterm rates of 12.8% in the US and 19.7% in Puerto Rico in 2005. Program goals fit within Multi-Year Plans of the EPA's Office of Research and Development and also within the EPA's strategic plan for compliance and environmental stewardship that strives for green cleanup programs. The program will address many of the SBRP goals, including understanding the relationship between exposure and disease etiology, translating innovative remediation technologies, and improving the risk assessment decision-making process.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES017198-03
Application #
8250025
Study Section
Special Emphasis Panel (ZES1-LWJ-M (O1))
Program Officer
Henry, Heather F
Project Start
2010-04-12
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
3
Fiscal Year
2012
Total Cost
$2,428,771
Indirect Cost
$483,598
Name
Northeastern University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115
Ferguson, Kelly K; Cantonwine, David E; McElrath, Thomas F et al. (2016) Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reprod Toxicol 66:93-98
Li, Dan; Zeng, Siyu; He, Miao et al. (2016) Water Disinfection Byproducts Induce Antibiotic Resistance-Role of Environmental Pollutants in Resistance Phenomena. Environ Sci Technol 50:3193-201
Ferguson, Kelly K; Meeker, John D; Cantonwine, David E et al. (2016) Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environ Int 94:531-7
Rajic, Ljiljana; Nazari, Roya; Fallahpour, Noushin et al. (2016) Electrochemical degradation of trichloroethylene in aqueous solution by bipolar graphite electrodes. J Environ Chem Eng 4:197-202
Rajic, Ljiljana; Fallahpour, Noushin; Podlaha, Elizabeth et al. (2016) The influence of cathode material on electrochemical degradation of trichloroethylene in aqueous solution. Chemosphere 147:98-104
McIntosh, Scott; Pérez-Ramos, José; Demment, Margaret M et al. (2016) Development and Implementation of Culturally Tailored Offline Mobile Health Surveys. JMIR Public Health Surveill 2:e28
Watkins, Deborah J; Fortenberry, Gamola Z; Sánchez, Brisa N et al. (2016) Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment. Environ Res 147:307-13
Tan, Wenbing; Zhang, Yuan; He, Xiaosong et al. (2016) Distribution patterns of phthalic acid esters in soil particle-size fractions determine biouptake in soil-cereal crop systems. Sci Rep 6:31987
Johns, Lauren E; Ferguson, Kelly K; Meeker, John D (2016) Relationships Between Urinary Phthalate Metabolite and Bisphenol A Concentrations and Vitamin D Levels in U.S. Adults: National Health and Nutrition Examination Survey (NHANES), 2005-2010. J Clin Endocrinol Metab 101:4062-4069
Shao, Gang; MacNeil, Michael; Yao, Yuanyuan et al. (2016) Porous extraction paddle: a solid phase extraction technique for studying the urine metabolome. Rapid Commun Mass Spectrom :

Showing the most recent 10 out of 116 publications