The PRoTECT program theme is to use Puerto Rico as a testsite with dynamic exposure pathways through karstic aquifers to study Superfund and related contaminants and their contributions to preterm birth. The goal of the Research Translation Core is to enable the knowledge gained from fundamental research to achieve the broadest impact on the wide community of people and organizations that deal with the diverse, real-world aspects of preterm birth. To do this the Research Translation Core uses a three-level strategic approach that focuses core activities on linking the research projects to real-world impacts. The three levels of this approach are: Fundamental Science (Level 1), Enabling Testbeds and Research Translation (Level 2) and the Grand Challenges and Impact on Public Health (Level 3). The Research Translation Core at Level 2 of this approach will serve to dynamically connect the useful knowledge (Level 1) with informed action (Level 3). The core aims to (a) partner with government agencies by (1) emphasizing the scientific significance and/or relevance of the program and (2) building direct partnerships with these agencies;(b) conduct Technology Transfer by (1) forming linkages between PRoTECT investigators and stakeholders and (2) collaborating with industry to jointly pursue field demonstrations and implementation;and (c) communicate with broad audiences by (1) maintaining user-friendly infrastructure and resources for effective and timely dissemination of program outcomes, and (2) providing communication resources to promote professional development and effective communication with the public. Specific activities will be conducted at both the research thrust and program-wide levels. By exchanging information and conducting joint tasks we will collaborate with government agencies (e.g. EPA, USGS, USACE) to translate basic research into implementation (by developing GIS and modeling systems and pursuing opportunities for demonstrations) at two sites in Puerto Rico. Program-wide activities include organizing an annual Research and Industry/Government Collaboration Conference, web-based dissemination of research, and webinars. Prof. Michael Silevitch, Core Leader, has over 20 years of experience leading multi-partner university Centers with broad impact. This experience will be leveraged by PRoTECT.

Public Health Relevance

A critical function of the PRoTECT program is accurate and timely use of research findings and translation of these findings to appropriate audiences and applications. The research translation core will serve to dynamically connect the useful knowledge with informed action. The approach fits within the modern science and technology enterprise which promotes the use-inspired basic research within the framework of Sustainability Science.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-LWJ-M)
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Northeastern University
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Watkins, Deborah J; Ferguson, Kelly K; Anzalota Del Toro, Liza V et al. (2015) Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. Int J Hyg Environ Health 218:212-9
Yu, Xue; Ghasemizadeh, Reza; Padilla, Ingrid et al. (2015) Spatiotemporal changes of CVOC concentrations in karst aquifers: analysis of three decades of data from Puerto Rico. Sci Total Environ 511:10-Jan
Ferguson, Kelly K; McElrath, Thomas F; Chen, Yin-Hsiu et al. (2015) Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. Am J Obstet Gynecol 212:208.e1-8
Boldenow, Erica; Hogan, Kelly A; Chames, Mark C et al. (2015) Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am J Reprod Immunol 73:263-72
Rajic, Ljiljana; Fallahpour, Noushin; Yuan, Songhu et al. (2014) Electrochemical transformation of trichloroethylene in aqueous solution by electrode polarity reversal. Water Res 67:267-75
Ferguson, Kelly K; Cantonwine, David E; Rivera-González, Luis O et al. (2014) Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol 48:7018-25
Ferguson, Kelly K; McElrath, Thomas F; Ko, Yi-An et al. (2014) Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environ Int 70:118-24
Korir, Michelle L; Knupp, David; LeMerise, Kathryn et al. (2014) Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun 82:4587-95
Yao, Yuanyuan; Wang, Poguang; Giese, Roger (2014) Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 28:653-61
Fortenberry, Gamola Z; Meeker, John D; Sánchez, Brisa N et al. (2014) Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico. Environ Res 132:342-9

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