The Puerto Rico Testsite for Exploring Contamination Threats Center (PROTECT) uses an integrated, cross- disciplinary approach to study the fate, transport, exposure, health impact and remediation of contaminants commonly found at Superfund sites, with particular attention to phthalates and chlorinated solvents as both are suspect and model agents in the high preterm birth rates in Puerto Rico. The Research Translation Core (RTC) serves the overall interests of PROTECT and NIEHS by translating and disseminating PROTECT research results to a wide variety of governmental agencies, scientific communities, industry, and other stakeholders. The RTC does this through five aims: ? Aim 1: Publicize and emphasize to EPA, ATSDR, and other stakeholders the significance and/or relevance of program findings for public policy, public health, and prevention ? Aim 2: Build partnerships with stakeholders to respond to requests, develop capacity, and improve understanding of Center findings ? Aim 3: Serve as the bridge between investigators, partners and stakeholders to foster commercial development, utilization and translation of the knowledge gained by the SRP program into tools, strategies or technologies, in an efficient and timely manner ? Aim 4: Collaborate with other PROTECT cores for enhanced sharing of information, materials and best practices outside of PROTECT ? Aim 5: Communicate PROTECT work to SRP Headquarters and to the national SRP community These aims are realized through activities that solidify internal communications within PROTECT, communications with other SRPs and the national office, and communication with a wide range of professional, governmental, public health, and community organizations. The RTC works with each project leader to develop translational activities, and it offers training sessions for faculty, postdocs, and students to facilitate research translation. The RTC develops mechanisms for technology transfer, such as patents, commercialization, and intellectual property. It facilitates consultations of expertise and new collaborations, particularly outside the SRP community. The RTC helps investigators to increase NIEHS and other grant submissions, thus expanding the environmental health capacity of the constituent campuses. It offers webinars and conferences to share findings and for communities to share experiences/needs with the university researchers, especially by collaborating with the Training Core and Community Engagement Core. The RTC has a strong website presence and is the central clearinghouse for collating and disseminating PROTECT results and materials. The RTC also develops publications that highlight the overall sum of PROTECT's research translation outcomes.

Public Health Relevance

PROTECT uses an integrated, cross-disciplinary approach to study the transport, exposure, health impact and remediation of contaminants commonly found at Superfund sites, with particular attention to phthalates and chlorinated solvents as both are suspect in the high preterm birth rates in Puerto Rico. The Research Translation Core coordinates PROTECT's efforts to translate and disseminate research results from all Center projects to stakeholders, to promote understanding of contaminant exposure and assist in public health education and intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES017198-05
Application #
8649390
Study Section
Special Emphasis Panel (ZES1-LKB-K (S))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
5
Fiscal Year
2014
Total Cost
$123,887
Indirect Cost
$44,217
Name
Northeastern University
Department
Type
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115
Ferguson, Kelly K; Colacino, Justin A; Lewis, Ryan C et al. (2017) Personal care product use among adults in NHANES: associations between urinary phthalate metabolites and phenols and use of mouthwash and sunscreen. J Expo Sci Environ Epidemiol 27:326-332
Elkin, Elana R; O'Neill, Marie S (2017) Trends in Environmental Tobacco Smoke (ETS) Exposure and Preterm Birth: Use of Smoking Bans and Direct ETS Exposure Assessments in Study Designs. Chem Res Toxicol 30:1376-1383
Ferguson, Kelly K; McElrath, Thomas F; Pace, Gerry G et al. (2017) Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women. Environ Sci Technol 51:4652-4660
Park, Hae-Ryung; Harris, Sean M; Boldenow, Erica et al. (2017) Group B Streptococcus Activates Transcriptomic Pathways Related to Premature Birth in Human Extraplacental Membranes In Vitro. Biol Reprod :
Ferguson, Kelly K; Meeker, John D; Cantonwine, David E et al. (2017) Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environ Int 112:243-250
Shao, Gang; Agar, Jeffrey; Giese, Roger W (2017) Cold-induced aqueous acetonitrile phase separation: A salt-free way to begin quick, easy, cheap, effective, rugged, safe. J Chromatogr A 1506:128-133
Wang, Poguang; Giese, Roger W (2017) Recommendations for quantitative analysis of small molecules by matrix-assisted laser desorption ionization mass spectrometry. J Chromatogr A 1486:35-41
Ferguson, Kelly K; Chen, Yin-Hsiu; VanderWeele, Tyler J et al. (2017) Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environ Health Perspect 125:488-494
Aung, Max T; Johns, Lauren E; Ferguson, Kelly K et al. (2017) Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environ Int 104:33-40
Yuan, Ye; Meeker, John D; Ferguson, Kelly K (2017) Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: The National Health and Nutrition Examination Survey 2003-2004. Sci Total Environ 575:400-405

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