The Puerto Rico Testsite for Exploring Contamination Threats Center (PROTECT) uses an integrated, cross- disciplinary approach to study the fate, transport, exposure, health impact and remediation of contaminants commonly found at Superfund sites, with particular attention to phthalates and chlorinated solvents as both are suspect and model agents in the high preterm birth rates in Puerto Rico. The Research Translation Core (RTC) serves the overall interests of PROTECT and NIEHS by translating and disseminating PROTECT research results to a wide variety of governmental agencies, scientific communities, industry, and other stakeholders. The RTC does this through five aims: ? Aim 1: Publicize and emphasize to EPA, ATSDR, and other stakeholders the significance and/or relevance of program findings for public policy, public health, and prevention ? Aim 2: Build partnerships with stakeholders to respond to requests, develop capacity, and improve understanding of Center findings ? Aim 3: Serve as the bridge between investigators, partners and stakeholders to foster commercial development, utilization and translation of the knowledge gained by the SRP program into tools, strategies or technologies, in an efficient and timely manner ? Aim 4: Collaborate with other PROTECT cores for enhanced sharing of information, materials and best practices outside of PROTECT ? Aim 5: Communicate PROTECT work to SRP Headquarters and to the national SRP community These aims are realized through activities that solidify internal communications within PROTECT, communications with other SRPs and the national office, and communication with a wide range of professional, governmental, public health, and community organizations. The RTC works with each project leader to develop translational activities, and it offers training sessions for faculty, postdocs, and students to facilitate research translation. The RTC develops mechanisms for technology transfer, such as patents, commercialization, and intellectual property. It facilitates consultations of expertise and new collaborations, particularly outside the SRP community. The RTC helps investigators to increase NIEHS and other grant submissions, thus expanding the environmental health capacity of the constituent campuses. It offers webinars and conferences to share findings and for communities to share experiences/needs with the university researchers, especially by collaborating with the Training Core and Community Engagement Core. The RTC has a strong website presence and is the central clearinghouse for collating and disseminating PROTECT results and materials. The RTC also develops publications that highlight the overall sum of PROTECT's research translation outcomes.

Public Health Relevance

PROTECT uses an integrated, cross-disciplinary approach to study the transport, exposure, health impact and remediation of contaminants commonly found at Superfund sites, with particular attention to phthalates and chlorinated solvents as both are suspect in the high preterm birth rates in Puerto Rico. The Research Translation Core coordinates PROTECT's efforts to translate and disseminate research results from all Center projects to stakeholders, to promote understanding of contaminant exposure and assist in public health education and intervention.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-LKB-K (S))
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Northeastern University
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Watkins, Deborah J; Ferguson, Kelly K; Anzalota Del Toro, Liza V et al. (2015) Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. Int J Hyg Environ Health 218:212-9
Yu, Xue; Ghasemizadeh, Reza; Padilla, Ingrid et al. (2015) Spatiotemporal changes of CVOC concentrations in karst aquifers: analysis of three decades of data from Puerto Rico. Sci Total Environ 511:10-Jan
Ferguson, Kelly K; McElrath, Thomas F; Chen, Yin-Hsiu et al. (2015) Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. Am J Obstet Gynecol 212:208.e1-8
Boldenow, Erica; Hogan, Kelly A; Chames, Mark C et al. (2015) Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am J Reprod Immunol 73:263-72
Rajic, Ljiljana; Fallahpour, Noushin; Yuan, Songhu et al. (2014) Electrochemical transformation of trichloroethylene in aqueous solution by electrode polarity reversal. Water Res 67:267-75
Ferguson, Kelly K; Cantonwine, David E; Rivera-González, Luis O et al. (2014) Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol 48:7018-25
Ferguson, Kelly K; McElrath, Thomas F; Ko, Yi-An et al. (2014) Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environ Int 70:118-24
Korir, Michelle L; Knupp, David; LeMerise, Kathryn et al. (2014) Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun 82:4587-95
Yao, Yuanyuan; Wang, Poguang; Giese, Roger (2014) Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 28:653-61
Fortenberry, Gamola Z; Meeker, John D; Sánchez, Brisa N et al. (2014) Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico. Environ Res 132:342-9

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