Overall Center Abstract: The Charleston Alcohol Research Center has had, and continues to have, alcohol treatment as the Center's overarching theme. Our Center continues to embrace a multidisciplinary approach to accomplish its objectives, with basic scientists working side-by-side with psychiatrists or clinical psychologists on athematic program of research. Junior investigators recruited into the Center are """"""""teamed"""""""" with more experienced investigators to provide them with a unique mentoring opportunity aimed at arming them with the necessary experience to become independent researchers. For this application, the research teams have taken advantage of developing or refining cutting-edge technologies (e.g., brain imaging, genetics, in vivo microdialysis, multi-array recording, and laboratory paradigms to study stress-alcohol interactions and/or voluntary drinking) to address their specific research questions. In the next five years, the Research Components are tied together by either a focus on neuroanatomical and/or neurochemical adaptations that accompany the transition from controlled to uncontrolled drinking, the neurocircuitry underlying reward processes, or trait personality factors that may mediate the risk for development of alcohol dependence or the response to medication. Pharmacotherapy, or implications for pharmacotherapy, remains the major focus of the Charleston Alcohol Research Center, and is the area where we have developed a national/international reputation. The Research Components are supported by two Cores and two other components. The Administrative Core provides the leadership and infrastructure to facilitate the mission of the Center as a Whole;the Shared Core provides and manages common services needed by the researchers to maximize resources and increase productivity;the Pilot Project Component attracts new talent or new ideas to the Center;and the Research Translation/Information Dissemination Component accomplishes the aim and responsibility of a Center for information dissemination on advances in alcohol research to the general public, as well as to health care providers.

Public Health Relevance

Overall Center Project Narrative: Alcoholism remains a major public health concern. Advances in neuroscience and genetics will help inform treatment-related research and will help identify risk factors, at the behavioral as well as neurochemical level, that indicate a risk for the development of alcohol dependence. This information will be useful for testing prevention as well as intervention strategies that, when transferred to clinical practice, will ultimately decrease the burden of excessive alcohol use on the individual, as well as on society.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-GG (99))
Program Officer
Huebner, Robert B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Rose, Jamie H; Karkhanis, Anushree N; Chen, Rong et al. (2016) Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacol 19:
Glover, Elizabeth J; McDougle, Molly J; Siegel, Griffin S et al. (2016) Role for the Rostromedial Tegmental Nucleus in Signaling the Aversive Properties of Alcohol. Alcohol Clin Exp Res 40:1651-61
Barker, Jacqueline M; Lench, Daniel H; Chandler, L Judson (2016) Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice. Psychopharmacology (Berl) 233:235-42
Lopez, Marcelo F; Moorman, David E; Aston-Jones, Gary et al. (2016) The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice. Brain Res 1636:74-80
Uys, Joachim D; McGuier, Natalie S; Gass, Justin T et al. (2016) Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol 21:560-74
den Hartog, Carolina; Zamudio-Bulcock, Paula; Nimitvilai, Sudarat et al. (2016) Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice. Neuropharmacology 107:451-9
Boyd, Stephen J; Schacht, Joseph P; Prisciandaro, James J et al. (2016) Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol 51:549-54
Lopez, Marcelo F; Anderson, Rachel I; Becker, Howard C (2016) Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. Alcohol 51:17-23
Nimitvilai, Sudarat; Lopez, Marcelo F; Mulholland, Patrick J et al. (2016) Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol. Neuropsychopharmacology 41:1112-27
Moorman, David E; James, Morgan H; Kilroy, Elisabeth A et al. (2016) Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner. Eur J Neurosci 43:710-20

Showing the most recent 10 out of 159 publications