Overall Center Abstract: The Charleston Alcohol Research Center has had, and continues to have, alcohol treatment as the Center's overarching theme. Our Center continues to embrace a multidisciplinary approach to accomplish its objectives, with basic scientists working side-by-side with psychiatrists or clinical psychologists on athematic program of research. Junior investigators recruited into the Center are """"""""teamed"""""""" with more experienced investigators to provide them with a unique mentoring opportunity aimed at arming them with the necessary experience to become independent researchers. For this application, the research teams have taken advantage of developing or refining cutting-edge technologies (e.g., brain imaging, genetics, in vivo microdialysis, multi-array recording, and laboratory paradigms to study stress-alcohol interactions and/or voluntary drinking) to address their specific research questions. In the next five years, the Research Components are tied together by either a focus on neuroanatomical and/or neurochemical adaptations that accompany the transition from controlled to uncontrolled drinking, the neurocircuitry underlying reward processes, or trait personality factors that may mediate the risk for development of alcohol dependence or the response to medication. Pharmacotherapy, or implications for pharmacotherapy, remains the major focus of the Charleston Alcohol Research Center, and is the area where we have developed a national/international reputation. The Research Components are supported by two Cores and two other components. The Administrative Core provides the leadership and infrastructure to facilitate the mission of the Center as a Whole;the Shared Core provides and manages common services needed by the researchers to maximize resources and increase productivity;the Pilot Project Component attracts new talent or new ideas to the Center;and the Research Translation/Information Dissemination Component accomplishes the aim and responsibility of a Center for information dissemination on advances in alcohol research to the general public, as well as to health care providers.

Public Health Relevance

Overall Center Project Narrative: Alcoholism remains a major public health concern. Advances in neuroscience and genetics will help inform treatment-related research and will help identify risk factors, at the behavioral as well as neurochemical level, that indicate a risk for the development of alcohol dependence. This information will be useful for testing prevention as well as intervention strategies that, when transferred to clinical practice, will ultimately decrease the burden of excessive alcohol use on the individual, as well as on society.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA010761-18
Application #
8403593
Study Section
Special Emphasis Panel (ZAA1-GG (99))
Program Officer
Huebner, Robert B
Project Start
1996-12-01
Project End
2015-12-31
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
18
Fiscal Year
2013
Total Cost
$1,610,516
Indirect Cost
$561,995
Name
Medical University of South Carolina
Department
Psychiatry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Laguesse, Sophie; Morisot, Nadege; Shin, Jung Hoon et al. (2017) Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron 96:145-159.e8
Cannady, Reginald; McGonigal, Justin T; Newsom, Ryan J et al. (2017) Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369
Anderson, Rachel I; Becker, Howard C (2017) Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol. Alcohol Clin Exp Res 41:1402-1418
Witkiewitz, Katie; Wilson, Adam D; Pearson, Matthew R et al. (2017) Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study. Alcohol Clin Exp Res 41:1054-1062
Litten, Raye Z; Falk, Daniel E; O'Malley, Stephanie S et al. (2017) Letter to Editor in Response to Johnson's Commentary (2017) on the Witkiewitz and Colleagues (2017) Article. Alcohol Clin Exp Res 41:1381-1382
Rinker, Jennifer A; Fulmer, Diana B; Trantham-Davidson, Heather et al. (2017) Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol 58:33-45
Nimitvilai, Sudarat; Lopez, Marcelo F; Mulholland, Patrick J et al. (2017) Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability. Neuropsychopharmacology 42:1800-1812
Trantham-Davidson, Heather; Centanni, Samuel W; Garr, S Corrin et al. (2017) Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex. Neuropsychopharmacology 42:1024-1036
Rinker, Jennifer A; Mulholland, Patrick J (2017) Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. Pharmacogenomics 18:555-570
Stewart, Scott H; Reuben, Adrian; Anton, Raymond F (2017) Relationship of Abnormal Chromatographic Pattern for Carbohydrate-Deficient Transferrin with Severe Liver Disease. Alcohol Alcohol 52:24-28

Showing the most recent 10 out of 179 publications