The Administrative Core is a critical part of the Charleston Alcohol Research Center since it acts as the coordinating center for seven components (two clinical research components, three basic research components, one research translation/Information dissemination component, and one pilot project component), and the Shared Core. This Core provides the organizational framework that is necessary for the effective and efficient management of Center resources. Under the supervision of the Director, the Administrative Core staff manages the day-to-day operations of the Center, addresses emergent and scientific issues, monitors all budgetary matters, defines and develops internal and external quality control mechanisms, integrates all the components of the Center, acts as a liaison between the Center and the local and regional community, and, provides professional development and scientific enrichment experiences. As the hub of the Charleston ARC, the Administrative Core must provide expert leadership and a strong organizational structure. The Administrative Core has had minimal turnover in leadership or staff since its inception. The Administrative Core is located in the Center for Drug and Alcohol Programs on the campus of the Medical University of South Carolina. The Director of the Administrative Core, the two Scientific Directors, and the Core's Administrative staff have offices in close proximity to each other. The leadership team is comprised of senior scientists with career commitments to alcohol research. Importantly, they represent both clinical and basic science backgrounds. This blend of scientific expertise facilitates the Center's interest in translational and interdisciplinary research. The Steering Committee serves to ensure internal communication and focuses on operational issues. The external Program Advisory Committee provides scientific direction and scientific interchange. In summary, the Administrative Core has an experienced and proven infrastructure that is well able to ensure that the Charleston Alcohol Research Center accomplishes the objectives defined in its mission statement.
An Alcohol Research Center, such as the one at the Medical University of South Carolina, that focuses on improving treatments for alcoholism is important because it brings together a multidisciplinary team of researchers to address a major health problem. If, through this research, new treatment or treatment targets can be identified, it may be possible to prevent the transition from controlled to uncontrolled drinking, thereby reducing the burden of alcohol abuse on the individual, the family, and society as a whole.
|Rose, Jamie H; Karkhanis, Anushree N; Chen, Rong et al. (2016) Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacol 19:|
|Glover, Elizabeth J; McDougle, Molly J; Siegel, Griffin S et al. (2016) Role for the Rostromedial Tegmental Nucleus in Signaling the Aversive Properties of Alcohol. Alcohol Clin Exp Res 40:1651-61|
|Barker, Jacqueline M; Lench, Daniel H; Chandler, L Judson (2016) Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice. Psychopharmacology (Berl) 233:235-42|
|Lopez, Marcelo F; Moorman, David E; Aston-Jones, Gary et al. (2016) The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice. Brain Res 1636:74-80|
|Uys, Joachim D; McGuier, Natalie S; Gass, Justin T et al. (2016) Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol 21:560-74|
|den Hartog, Carolina; Zamudio-Bulcock, Paula; Nimitvilai, Sudarat et al. (2016) Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice. Neuropharmacology 107:451-9|
|Boyd, Stephen J; Schacht, Joseph P; Prisciandaro, James J et al. (2016) Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol 51:549-54|
|Lopez, Marcelo F; Anderson, Rachel I; Becker, Howard C (2016) Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. Alcohol 51:17-23|
|Nimitvilai, Sudarat; Lopez, Marcelo F; Mulholland, Patrick J et al. (2016) Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol. Neuropsychopharmacology 41:1112-27|
|Moorman, David E; James, Morgan H; Kilroy, Elisabeth A et al. (2016) Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner. Eur J Neurosci 43:710-20|
Showing the most recent 10 out of 159 publications