The Shared Core provides centralized services needed by investigators in the Charleston Alcohol Research Center (ARC). Since its inception, the Shared Core has been a valuable part of the ARC, achieving its goals and refining its services to best meet the needs of a dynamic research environment. The proposed Shared Core contains two new services identified as important by Center researchers, the Animal Model Core and the Genotyping Core, while retaining the highly valued and widely utilized Biostatistics Core. - The Animal Model Core will provide basic science researchers in the Center with mice that have been treated in a standardized, well-validated ethanol dependence model. This will facilitate integration of data collected from the various Center projects including electrophysiological, neurochemical, and behavioral measures that will be related to consequences of chronic intermittent ethanol exposure using a single model. - The Genotyping Core will support the Center's increasing needs for advanced genetic analysis. Although this service will predominantly support clinical research projects in the ARC, extending this core function to other clinical as well as preclinical projects will enhance translational efforts in the Center. - The Biostatistics Core will continue to provide data management and expert statistical analysis and consulting service to all Center research projects through the Office of Statistics and Database Management. By centralizing these services, several important benefits are realized. First, the Shared Core provides needed expertise in specialized areas. Second, it affords a more efficient and standardized research environment, as it prevents the duplication of effort by individual research groups. Third, the Shared Core provides time- and cost-savings for all research studies that utilize the services. Finally, the Shared Core system fosters greater integration of Center research activities and it provides a central authority for quality control over provision and utilization of services as well as ensuring that its services meet the needs of Center investigators.

Public Health Relevance

The Shared Core contains the Animal Model Core, Genotyping Core, and Biostatistics Core and provides these valuable services to all research components and pilot projects in the Charleston ARC. By centralizing these services, the Shared Core promotes integrative, efficient, and high quality research activities that facilitate the Center in successfully meeting its overall research goals and mission.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
United States
Zip Code
Laguesse, Sophie; Morisot, Nadege; Shin, Jung Hoon et al. (2017) Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron 96:145-159.e8
Cannady, Reginald; McGonigal, Justin T; Newsom, Ryan J et al. (2017) Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369
Anderson, Rachel I; Becker, Howard C (2017) Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol. Alcohol Clin Exp Res 41:1402-1418
Witkiewitz, Katie; Wilson, Adam D; Pearson, Matthew R et al. (2017) Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study. Alcohol Clin Exp Res 41:1054-1062
Litten, Raye Z; Falk, Daniel E; O'Malley, Stephanie S et al. (2017) Letter to Editor in Response to Johnson's Commentary (2017) on the Witkiewitz and Colleagues (2017) Article. Alcohol Clin Exp Res 41:1381-1382
Rinker, Jennifer A; Fulmer, Diana B; Trantham-Davidson, Heather et al. (2017) Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol 58:33-45
Nimitvilai, Sudarat; Lopez, Marcelo F; Mulholland, Patrick J et al. (2017) Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability. Neuropsychopharmacology 42:1800-1812
Trantham-Davidson, Heather; Centanni, Samuel W; Garr, S Corrin et al. (2017) Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex. Neuropsychopharmacology 42:1024-1036
Rinker, Jennifer A; Mulholland, Patrick J (2017) Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. Pharmacogenomics 18:555-570
Stewart, Scott H; Reuben, Adrian; Anton, Raymond F (2017) Relationship of Abnormal Chromatographic Pattern for Carbohydrate-Deficient Transferrin with Severe Liver Disease. Alcohol Alcohol 52:24-28

Showing the most recent 10 out of 179 publications