The Shared Core provides centralized services needed by investigators in the Charleston Alcohol Research Center (ARC). Since its inception, the Shared Core has been a valuable part of the ARC, achieving its goals and refining its services to best meet the needs of a dynamic research environment. The proposed Shared Core contains two new services identified as important by Center researchers, the Animal Model Core and the Genotyping Core, while retaining the highly valued and widely utilized Biostatistics Core. - The Animal Model Core will provide basic science researchers in the Center with mice that have been treated in a standardized, well-validated ethanol dependence model. This will facilitate integration of data collected from the various Center projects including electrophysiological, neurochemical, and behavioral measures that will be related to consequences of chronic intermittent ethanol exposure using a single model. - The Genotyping Core will support the Center's increasing needs for advanced genetic analysis. Although this service will predominantly support clinical research projects in the ARC, extending this core function to other clinical as well as preclinical projects will enhance translational efforts in the Center. - The Biostatistics Core will continue to provide data management and expert statistical analysis and consulting service to all Center research projects through the Office of Statistics and Database Management. By centralizing these services, several important benefits are realized. First, the Shared Core provides needed expertise in specialized areas. Second, it affords a more efficient and standardized research environment, as it prevents the duplication of effort by individual research groups. Third, the Shared Core provides time- and cost-savings for all research studies that utilize the services. Finally, the Shared Core system fosters greater integration of Center research activities and it provides a central authority for quality control over provision and utilization of services as well as ensuring that its services meet the needs of Center investigators.
The Shared Core contains the Animal Model Core, Genotyping Core, and Biostatistics Core and provides these valuable services to all research components and pilot projects in the Charleston ARC. By centralizing these services, the Shared Core promotes integrative, efficient, and high quality research activities that facilitate the Center in successfully meeting its overall research goals and mission.
|Dowdle, Logan T; Brown, Truman R; George, Mark S et al. (2018) Single pulse TMS to the DLPFC, compared to a matched sham control, induces a direct, causal increase in caudate, cingulate, and thalamic BOLD signal. Brain Stimul 11:789-796|
|Zamudio-Bulcock, Paula A; Homanics, Gregg E; Woodward, John J (2018) Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit. Alcohol Clin Exp Res 42:698-705|
|Cannady, Reginald; Rinker, Jennifer A; Nimitvilai, Sudarat et al. (2018) Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol 248:311|
|Harlan, Benjamin A; Becker, Howard C; Woodward, John J et al. (2018) Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. Neuropsychopharmacology 43:2064-2074|
|Hanlon, Colleen A; Dowdle, Logan T; Henderson, J Scott (2018) Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development. Pharmacol Rev 70:661-683|
|Hanlon, Colleen A; Dowdle, Logan T; Gibson, Nicole B et al. (2018) Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex. Transl Psychiatry 8:186|
|Gioia, Dominic A; Xu, Minfu; Wayman, Wesley N et al. (2018) Effects of drugs of abuse on channelrhodopsin-2 function. Neuropharmacology 135:316-327|
|Anton, Raymond F; Latham, Patricia K; Voronin, Konstantin E et al. (2018) Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. Alcohol Clin Exp Res 42:751-760|
|Anderson, Ethan M; Larson, Erin B; Guzman, Daniel et al. (2018) Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety. J Neurosci 38:803-813|
|Osterndorff-Kahanek, Elizabeth A; Tiwari, Gayatri R; Lopez, Marcelo F et al. (2018) Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. PLoS One 13:e0190841|
Showing the most recent 10 out of 209 publications