The Pilot Projects Core provides a mechanism to provide a limited amount of funding to investigators to collect pilot data for innovative research projects. These projects serve the CTNA by 1) testing hypotheses or addressing methodologic issues central to the CTNA, 2) bringing new investigators into the CTNA and the field of alcoholism research, 3) generating new alcoholism RO1's, 4) enabling CTNA to rapidly adapt to advances in the field, and 5) guiding the next iteration of the CTNA. Pilot Project Proposals are solicited through an open and public solicitation process. Proposal are developed in collaboration with the CTNA Cores (Data Management and Biostatistics, Clinical, Genetics) and refined with feedback from the Executive Committee. The following four studies are proposed for the first two years of CTNA funding: 1) Dana Small, Ph.D. will lead the first human functional neuroimaging (fMRI) study to describe the neural circuitry underlying alcohol-related habit formation. 2) Philip Corlett, Ph.D. will initially conduct a behavior/electrophysiology study and then, building on this, conduct an fMRI study to explore neural mechanisms related to the impact of alcohol-related learning upon attention. 3) Anissa Abi-Dargham, M.D. will conduct the first evaluation of alterations in cortical dopamine release associated with alcohol dependence, using the new radiotracer [11C]FLB457 and positron emission tomorgraphy (PET). We also briefly describe additional outstanding proposals under consideration for the outlying years (3-5) of CTNA.

Public Health Relevance

The Pilot Core substantially extends the CTNA capacity to move rapidly in innovative new directions that enhance the impact of the Center on advancing the understanding of brain mechanisms that drive the human propensity to abuse alcohol and testing novel therapeutic agents based on our this unfolding biology. As a result, the Pilot Core adds value to the overall CTNA missions to provide a scientific foundation for novel prevention and treatment strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA012870-13
Application #
8467665
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
13
Fiscal Year
2013
Total Cost
$140,064
Indirect Cost
$28,981
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Krystal, John H (2016) Neuroethology as a translational neuroscience strategy in the era of the NIMH Research Domain Criteria. Psychophysiology 53:364-6
Clarke, Toni-Kim; Smith, Andrew H; Gelernter, Joel et al. (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addict Biol 21:469-80
Duman, Ronald S; Aghajanian, George K; Sanacora, Gerard et al. (2016) Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med 22:238-49
Wang, Fan; Xu, Hongqin; Zhao, Hongyu et al. (2016) DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Sci Rep 6:19430
Tsai, Wan-Min; Zhang, Heping; Buta, Eugenia et al. (2016) A modified classification tree method for personalized medicine decisions. Stat Interface 9:239-253
Wrocklage, Kristen M; Schweinsburg, Brian C; Krystal, John H et al. (2016) Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. J Int Neuropsychol Soc 22:399-411
Wang, Qian; Polimanti, Renato; Kranzler, Henry R et al. (2016) Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Hum Genet :
Steele, Vaughn R; Anderson, Nathaniel E; Claus, Eric D et al. (2016) Neuroimaging measures of error-processing: Extracting reliable signals from event-related potentials and functional magnetic resonance imaging. Neuroimage 132:247-60
Morean, M E; Zellers, S; Tamler, M et al. (2016) Psychometric validation of measures of alcohol expectancies, retrospective subjective response, and positive drinking consequences for use with adolescents. Addict Behav 58:182-7
Arout, Caroline A; Perrino Jr, Albert C; Ralevski, Elizabeth et al. (2016) Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects. Alcohol Clin Exp Res 40:1425-9

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