The gap between basic research advances and new clinical insights and treatments remains a critical obstacle to progress in the field of alcoholism research. This translational neuroscience mission is the enduring focus of the Center for the Translational Neuroscience of Alcoholism (CTNA). CTNA conducts groundbreaking molecular neuroscience, molecular genetics, functional and chemical neuroimaging, and psychopharmacology studies in the service of providing new insights to bridge the gap between basic and clinical research. This renewal application will study mechanisms through which disturbances in glutamate and dopamine neurotransmission within cortico-limbic circuitry promote the development of pathological drinking. Building on this perspective and its prior achievements, CTNA will explore novel approaches to the pharmacotherapy of alcoholism. CTNA will facilitate transdisciplinary research within projects and across projects. It will also continue its highly productive Pilot Projects Core that provides an open competitive mechanism to enable the Center to rapidly encompass innovative new research and to engage outstanding investigators new to alcoholism research. CTNA will continue to expand its educational mission, building on the success of the NIAAA Research Fellowship and the International Conference on the Applications of Neuroimaging to Alcoholism.
The projects outlined in this renewal application address brain mechanisms through which the heritable risk for alcoholism evolves into human alcoholism. In so doing, it may guide the development of novel preventive strategies. It addresses the public health impact of alcoholism by testing novel treatments for pathological drinking.
|Chang, Fong; Xu, Ke; Huang, Ming-Chyi et al. (2017) Alcohol Triggers Reemergence of Ketamine-Like Experience in a Ketamine Ex-User. J Clin Psychopharmacol 37:110-112|
|Wang, Qian; Polimanti, Renato; Kranzler, Henry R et al. (2017) Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Hum Genet 136:75-83|
|Kort, Naomi S; Ford, Judith M; Roach, Brian J et al. (2017) Role of N-Methyl-D-Aspartate Receptors in Action-Based Predictive Coding Deficits in Schizophrenia. Biol Psychiatry 81:514-524|
|Krystal, John H; Petrakis, Ismene L; O'Malley, Stephanie et al. (2017) NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide. Int J Neuropsychopharmacol 20:351-353|
|Polimanti, Renato; Gelernter, Joel (2017) ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet :|
|Polimanti, Renato; Jensen, Kevin P; Gelernter, Joel (2017) Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers. Sci Rep 7:1034|
|Polimanti, Renato; Agrawal, Arpana; Gelernter, Joel (2017) Schizophrenia and substance use comorbidity: a genome-wide perspective. Genome Med 9:25|
|Polimanti, Renato; Gelernter, Joel; Stein, Dan J (2017) Genetically determined schizophrenia is not associated with impaired glucose homeostasis. Schizophr Res :|
|Polimanti, Renato; Wang, Qian; Meda, Shashwath A et al. (2017) The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology 42:598-605|
|Polimanti, Renato; Meda, Shashwath A; Pearlson, Godfrey D et al. (2017) S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. J Psychiatry Neurosci 42:252-261|
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