The gap between basic research advances and new clinical insights and treatments remains a critical obstacle to progress in the field of alcoholism research. This translational neuroscience mission is the enduring focus of the Center for the Translational Neuroscience of Alcoholism (CTNA). CTNA conducts groundbreaking molecular neuroscience, molecular genetics, functional and chemical neuroimaging, and psychopharmacology studies in the service of providing new insights to bridge the gap between basic and clinical research. This renewal application will study mechanisms through which disturbances in glutamate and dopamine neurotransmission within cortico-limbic circuitry promote the development of pathological drinking. Building on this perspective and its prior achievements, CTNA will explore novel approaches to the pharmacotherapy of alcoholism. CTNA will facilitate transdisciplinary research within projects and across projects. It will also continue its highly productive Pilot Projects Core that provides an open competitive mechanism to enable the Center to rapidly encompass innovative new research and to engage outstanding investigators new to alcoholism research. CTNA will continue to expand its educational mission, building on the success of the NIAAA Research Fellowship and the International Conference on the Applications of Neuroimaging to Alcoholism.

Public Health Relevance

The projects outlined in this renewal application address brain mechanisms through which the heritable risk for alcoholism evolves into human alcoholism. In so doing, it may guide the development of novel preventive strategies. It addresses the public health impact of alcoholism by testing novel treatments for pathological drinking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA012870-14
Application #
8668811
Study Section
Special Emphasis Panel (ZAA1-GG (99))
Program Officer
Witt, Ellen
Project Start
2001-06-04
Project End
2016-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
14
Fiscal Year
2014
Total Cost
$1,523,916
Indirect Cost
$326,822
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Krystal, John H (2016) Neuroethology as a translational neuroscience strategy in the era of the NIMH Research Domain Criteria. Psychophysiology 53:364-6
Clarke, Toni-Kim; Smith, Andrew H; Gelernter, Joel et al. (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addict Biol 21:469-80
Duman, Ronald S; Aghajanian, George K; Sanacora, Gerard et al. (2016) Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med 22:238-49
Wang, Fan; Xu, Hongqin; Zhao, Hongyu et al. (2016) DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Sci Rep 6:19430
Tsai, Wan-Min; Zhang, Heping; Buta, Eugenia et al. (2016) A modified classification tree method for personalized medicine decisions. Stat Interface 9:239-253
Wrocklage, Kristen M; Schweinsburg, Brian C; Krystal, John H et al. (2016) Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. J Int Neuropsychol Soc 22:399-411
Wang, Qian; Polimanti, Renato; Kranzler, Henry R et al. (2016) Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Hum Genet :
Steele, Vaughn R; Anderson, Nathaniel E; Claus, Eric D et al. (2016) Neuroimaging measures of error-processing: Extracting reliable signals from event-related potentials and functional magnetic resonance imaging. Neuroimage 132:247-60
Morean, M E; Zellers, S; Tamler, M et al. (2016) Psychometric validation of measures of alcohol expectancies, retrospective subjective response, and positive drinking consequences for use with adolescents. Addict Behav 58:182-7
Arout, Caroline A; Perrino Jr, Albert C; Ralevski, Elizabeth et al. (2016) Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects. Alcohol Clin Exp Res 40:1425-9

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