The Pilot Project Component is designed to provide a flexible means for developing and exploring new research activities or directions, and unique opportunities that can evolve into independently funded research projects. During Years 6-10 we propose funding two pilot projects per year with a budget of about $50,000 per project. The expected duration of these projects will be 1 year; projects can be extended to two years upon successful competitive renewal. The Center Scientific Director will manage this Component. Pilot Project applications will be solicited annually from EGCRC and UCSF investigators. Each proposal will be evaluated for scientific merit, innovation, and for relatedness to the Center s overall goals by at least two members of the ACTG Program Advisory Board, the Scientific Director, and the Center Director. Recommendations for funding will be considered for approval by the Center Steering Committee. Two Pilot Projects have been proposed and awarded funding for Year 06.Project 7A (A. Kayser, Director) will examine whether the Delta Opioid Receptor (DOR) agonist, ALK33, can be a potential drug to treat alcohol intake and craving in a preclinical human trial. Experiments in human subjects are also aimed to conducted fMRI studies to determine whether the increase the connectivity between the medial prefrontal cortex and brain regions associated with reward and anxiety.
The Pilot Projects Core will oversee and monitor the progress of current Pilots. The Core will also be in charge of soliciting new proposals; managing the review process and making sure that the Pilot Projects supported by the ACTG are of high scientific quality and adhere to the overall mission of the Center as a whole.
|Lei, Kelly; Wegner, Scott A; Yu, Ji-Hwan et al. (2016) Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice. Neuropharmacology 110:431-7|
|Ron, Dorit; Barak, Segev (2016) Molecular mechanisms underlying alcohol-drinking behaviours. Nat Rev Neurosci 17:576-91|
|Darcq, Emmanuel; Morisot, Nadege; Phamluong, Khanhky et al. (2016) The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci 36:10116-27|
|Lei, Kelly; Wegner, Scott A; Yu, Ji-Hwan et al. (2016) A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice. Alcohol 55:9-16|
|Yang, Sungchil; Ben-Shalom, Roy; Ahn, Misol et al. (2016) Î²-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep 16:1518-26|
|Laguesse, Sophie; Morisot, Nadege; Phamluong, Khanhky et al. (2016) Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol :|
|Warnault, Vincent; Darcq, Emmanuel; Morisot, Nadege et al. (2016) The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry 79:463-73|
|Beckley, Jacob T; Laguesse, Sophie; Phamluong, Khanhky et al. (2016) The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci 36:701-13|
|Blasio, Angelo; Messing, Robert O (2016) Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2? Biol Psychiatry 79:425-6|
|Maiya, Rajani; McMahon, Thomas; Wang, Dan et al. (2016) Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology 107:40-8|
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