The Administrative Core will perform the centralized administrative functions for all 3 Research Components (Components 4-6) and the Pilot Projects (Component 7). It also will coordinate the activities of the Scientific Support Cores (Components 2-3). The Program Advisory Board will provide scientific oversight, and the Steering Committee will make executive decisions regarding ACTG activities. The Steering Committee will set goals, evaluate progress toward general scientific research directions, and oversee quality control mechanisms in all areas of Center activity. Oversight also will be provided for behavioral assays, production of viral vectors for gene silencing and transgenic expression, and imaging and histological analyses. The Administrative Core will also sponsor enrichment activities, including guest speakers, a course on the Neurobiology of Addiction for the UCSF Neuroscience Graduate Program, and an ACTG website to publicize ACTG-sponsored events, staff openings and links to other organizations? websites. There will be two lines of administrative responsibility within the Administrative Core. Dr. Messing, the Center Director, will supervise the general coordination of all Center administrative activities and the Center?s budget. Dr. Ron, the Scientific Director, will supervise the coordination of and future planning for scientific directions

Public Health Relevance

The Administrative Core will manage all operations of the ACTG, oversee the research, manage the budget, ensure quality control, and promote opportunities for training and education, with the overall mission of ensuring progress toward accomplishing the scientific goals of the Center as a whole

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA017072-08
Application #
8687560
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Wegner, Scott A; Pollard, Katherine A; Kharazia, Viktor et al. (2017) Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res 41:345-358
Morisot, N; Ron, D (2017) Alcohol-dependent molecular adaptations of the NMDA receptor system. Genes Brain Behav 16:139-148
Rinetti-Vargas, Gina; Phamluong, Khanhky; Ron, Dorit et al. (2017) Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment. Cell Rep 20:21-29
Liu, F; Laguesse, S; Legastelois, R et al. (2017) mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. Mol Psychiatry 22:89-101
Hopf, F W (2017) Do specific NMDA receptor subunits act as gateways for addictive behaviors? Genes Brain Behav 16:118-138
Blasio, Angelo; Wang, Jingyi; Wang, Dan et al. (2017) Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice. Biol Psychiatry :
Phamluong, Khanhky; Darcq, Emmanuel; Wu, Su et al. (2017) Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum. Front Mol Neurosci 10:273
Laguesse, Sophie; Morisot, Nadege; Phamluong, Khanhky et al. (2017) Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol 22:1856-1869
Fan, QiWen; Aksoy, Ozlem; Wong, Robyn A et al. (2017) A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell 31:424-435
Yang, Sungchil; Ben-Shalom, Roy; Ahn, Misol et al. (2016) ?-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep 16:1518-1526

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