The Administrative Core will perform the centralized administrative functions for all 3 Research Components (Components 4-6) and the Pilot Projects (Component 7). It also will coordinate the activities of the Scientific Support Cores (Components 2-3). The Program Advisory Board will provide scientific oversight, and the Steering Committee will make executive decisions regarding ACTG activities. The Steering Committee will set goals, evaluate progress toward general scientific research directions, and oversee quality control mechanisms in all areas of Center activity. Oversight also will be provided for behavioral assays, production of viral vectors for gene silencing and transgenic expression, and imaging and histological analyses. The Administrative Core will also sponsor enrichment activities, including guest speakers, a course on the Neurobiology of Addiction for the UCSF Neuroscience Graduate Program, and an ACTG website to publicize ACTG-sponsored events, staff openings and links to other organizations? websites. There will be two lines of administrative responsibility within the Administrative Core. Dr. Messing, the Center Director, will supervise the general coordination of all Center administrative activities and the Center?s budget. Dr. Ron, the Scientific Director, will supervise the coordination of and future planning for scientific directions

Public Health Relevance

The Administrative Core will manage all operations of the ACTG, oversee the research, manage the budget, ensure quality control, and promote opportunities for training and education, with the overall mission of ensuring progress toward accomplishing the scientific goals of the Center as a whole

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50AA017072-08
Application #
8794379
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94608
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Yang, Sungchil; Ben-Shalom, Roy; Ahn, Misol et al. (2016) β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep 16:1518-26
Laguesse, Sophie; Morisot, Nadege; Phamluong, Khanhky et al. (2016) Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol :
Warnault, Vincent; Darcq, Emmanuel; Morisot, Nadege et al. (2016) The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry 79:463-73
Beckley, Jacob T; Laguesse, Sophie; Phamluong, Khanhky et al. (2016) The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci 36:701-13
Blasio, Angelo; Messing, Robert O (2016) Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2? Biol Psychiatry 79:425-6
Maiya, Rajani; McMahon, Thomas; Wang, Dan et al. (2016) Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology 107:40-8

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