Recent data implicate the K opioid system in ethanol acceptance and reinforcement during infancy and adulthood. Pharmacological blockade of K opioid receptors enhances ethanol intake and reinforcing properties in adult rodents, whereas endogenous activity at K receptors is essential for infants to find ethanol appetitive. Furthermore, activation of the K opioid system is aversive for adult rats. In contrast, in infant rats, central activation of this system is extremely reinforcing. The present proposal will test the hypothesis that the K opioid system switches from mediating appetitive to aversive properties of ethanol between the first and the second postnatal week and that this ontogenetic switch occurs when motivational properties of K opioid activation become aversive instead of appetitive. Finally, changes in the K opioid system following central ethanol administration will be assessed during the first two weeks of postnatal life.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA017823-05
Application #
8537107
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$14,420
Indirect Cost
$3,852
Name
State University of NY, Binghamton
Department
Type
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902
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