Ethanol neurotoxicity affects neurotransmitter release. Experiments will be carried to test the hypothesis that ethanol exposure results in structural and biochemical changes in presynaptic terminals. First, a transgenic mouse that expresses yellow fluorescent protein (YFP) in a subset of cerebellar mossy fiber terminals will be used to determine whether ethanol treatment affects the size of the mossy fiber terminals. Second, the effect of ethanol on presynaptic protein SNAP-25 will be determined. These experiments will provide novel insights on how ethanol affects cerebellar circuitry at presynaptic terminals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
5P50AA017823-05
Application #
8537109
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$7,688
Indirect Cost
$2,053
Name
State University of NY, Binghamton
Department
Type
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902
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