A primary goal of the DEARC is to elucidate the brain and behavioral consequences of ethanol exposure throughout a broad range of developmental stages encompassing gestation through adulthood. All projects described in this center proposal utilize rodent models, making the Animal/Behavior Core a critical component of the DEARC. The Animal/Behavior Core plays several key roles within the center: It provides guidance and training on breeding practices, ethanol exposure, surgical techniques and behavioral phenotyping. In addition, the Animal/Behavioral Core provides access to equipment for behavioral assessment and measurement of ethanol in blood and brain. Another major goal of the Animal/Behavior Core is to facilitate the sharing of animal resources through an interactive on-line database. These goals will be facilitated by the core PI and Col, each with more than a dozen years of experience. The Animal/Behavior Core will be critical in maintaining the over arching goal of the DEARC of cross-study comparisons to understand how developmental ethanol exposure changes brain and behavioral function across the lifespan. Specifically the Animal/Behavior Core will streamline the generation, use, and distribution of animal resources, while at the same time providing crucial support for the standardization of techniques, thereby assuring quality control. Finally, the Animal/Behavior Core will play an essential role in promoting cross talk among Pis and between the Pis and the Administrative Core.

Public Health Relevance

Understanding now exposure to alcohol at a young age leads to increased prevalence of alcoholism is key to reducing the health burden of alcohol abuse. Animal models provide a critical approach to understanding the short and long-term brain and behavioral consequences of alcohol exposure. The Animal/Behavior Core of the DEARC provides critical support for the research group to characterize the brain/behavioral adoptions that emerge as a result of alcohol exposure at various developmental stages.

National Institute of Health (NIH)
Specialized Center (P50)
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Special Emphasis Panel (ZAA1)
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State University of NY, Binghamton
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Mantella, Nicole M; Youngentob, Steven L (2014) Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats. PLoS One 9:e102255
Santerre, Jessica L; Gigante, Eduardo D; Landin, Justine D et al. (2014) Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure. Psychopharmacology (Berl) 231:1809-20
Doremus-Fitzwater, Tamara L; Buck, Hollin M; Bordner, Kelly et al. (2014) Intoxication- and withdrawal-dependent expression of central and peripheral cytokines following initial ethanol exposure. Alcohol Clin Exp Res 38:2186-98
Gigante, Eduardo D; Santerre, Jessica L; Carter, Jenna M et al. (2014) Adolescent and adult rat cortical protein kinase A display divergent responses to acute ethanol exposure. Alcohol 48:463-70
Miranda-Morales, Roberto Sebastián; Nizhnikov, Michael E; Waters, Dustin H et al. (2014) New evidence of ethanol's anxiolytic properties in the infant rat. Alcohol 48:367-74
Fabio, Maria Carolina; Nizhnikov, Michael E; Spear, Norman E et al. (2014) Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats. Dev Psychobiol 56:574-83
Anderson, Rachel I; Morales, Melissa; Spear, Linda P et al. (2014) Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats. Psychopharmacology (Berl) 231:1687-93
Varlinskaya, Elena I; Mooney, Sandra M (2014) Acute exposure to ethanol on gestational day 15 affects social motivation of female offspring. Behav Brain Res 261:106-9
Nizhnikov, Michael E; Kozlov, Andrey P; Kramskaya, Tatiana A et al. (2014) Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats. Behav Brain Res 260:119-30
Anderson, Rachel I; Spear, Linda P (2014) Age differences in ethanol discrimination: acquisition and ethanol dose generalization curves following multiple training conditions in adolescent and adult rats. Alcohol Clin Exp Res 38:186-94

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