The Scientific Core will be a shared, research resource that provides investigators with services, expertise and equipment that will support, enhance and integrate the'^animal and human studies, thereby promoting the common goals of the Center. The Scientific Core will consolidate and standardize prenatal alcohol exposure procedures and mouse colony management. In addition to reducing research costs, this will allow investigators to query relationships between their findings and those obtained in other research components and, thus, facilitate integration of the research components. The Scientific Core will also manage the mouse behavioral facility that will be used for studies proposed in several Center components. The Scientific Core will also support the development of new research directions by assisting investigators with implementation of novel, behavioral and alcohol exposure paradigms. The Scientific Core v/ill provide statistical support for all of the research components, and will promote interaction among all Center investigators by providing a formal monthly forum for data presentation and discussion of potential collaborations. These monthly Synergy Meetings will aim to integrate the PSO components and foster the development of translational research efforts. Finally, in addition to providing services to the individual research components of the Center, the Scientific Core will, on a limited basis, support independently funded research project grants related to the Center's theme, thereby helping to expand the breadth of the Center's research activities.

Public Health Relevance

The Scientific Core will be a shared, research resource that provides investigators with services, expertise and equipment that will support, enhance and integrate the animal and human studies, thereby promoting the common goals of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
1P50AA022534-01
Application #
8600484
Study Section
Special Emphasis Panel (ZAA1-GG (50))
Project Start
Project End
Budget Start
2014-08-05
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$232,197
Indirect Cost
$78,424
Name
University of New Mexico Health Sciences Center
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Rodriguez, Carlos I; Davies, Suzy; Calhoun, Vince et al. (2016) Moderate Prenatal Alcohol Exposure Alters Functional Connectivity in the Adult Rat Brain. Alcohol Clin Exp Res 40:2134-2146
Marquardt, Kristin; Brigman, Jonathan L (2016) The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models. Alcohol 51:1-15
Morton, Russell A; Valenzuela, C Fernando (2016) Further characterization of the effect of ethanol on voltage-gated Ca(2+) channel function in developing CA3 hippocampal pyramidal neurons. Brain Res 1633:19-26
Kajimoto, Kenta; Valenzuela, C Fernando; Allan, Andrea M et al. (2016) Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment. Hippocampus 26:1078-87
Morton, Russell A; Valenzuela, C Fernando (2016) Third Trimester Equivalent Alcohol Exposure Reduces Modulation of Glutamatergic Synaptic Transmission by 5-HT1A Receptors in the Rat Hippocampal CA3 Region. Front Neurosci 10:266
Welch, J H; Mayfield, J J; Leibowitz, A L et al. (2016) Third trimester-equivalent ethanol exposure causes micro-hemorrhages in the rat brain. Neuroscience 324:107-18
Nirgudkar, Pranita; Taylor, Devin H; Yanagawa, Yuchio et al. (2016) Ethanol exposure during development reduces GABAergic/glycinergic neuron numbers and lobule volumes in the mouse cerebellar vermis. Neurosci Lett 632:86-91
Weick, Jason P (2016) Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease. Stem Cells Int 2016:4190438
Izquierdo, A; Brigman, J L; Radke, A K et al. (2016) The neural basis of reversal learning: An updated perspective. Neuroscience :
Topper, Lauren A; Baculis, Brian C; Valenzuela, C Fernando (2015) Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus. J Neuroinflammation 12:160

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