The Scientific Core will be a shared, research resource that provides investigators with services, expertise and equipment that will support, enhance and integrate the'^animal and human studies, thereby promoting the common goals of the Center. The Scientific Core will consolidate and standardize prenatal alcohol exposure procedures and mouse colony management. In addition to reducing research costs, this will allow investigators to query relationships between their findings and those obtained in other research components and, thus, facilitate integration of the research components. The Scientific Core will also manage the mouse behavioral facility that will be used for studies proposed in several Center components. The Scientific Core will also support the development of new research directions by assisting investigators with implementation of novel, behavioral and alcohol exposure paradigms. The Scientific Core v/ill provide statistical support for all of the research components, and will promote interaction among all Center investigators by providing a formal monthly forum for data presentation and discussion of potential collaborations. These monthly Synergy Meetings will aim to integrate the PSO components and foster the development of translational research efforts. Finally, in addition to providing services to the individual research components of the Center, the Scientific Core will, on a limited basis, support independently funded research project grants related to the Center's theme, thereby helping to expand the breadth of the Center's research activities.

Public Health Relevance

The Scientific Core will be a shared, research resource that provides investigators with services, expertise and equipment that will support, enhance and integrate the animal and human studies, thereby promoting the common goals of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Specialized Center (P50)
Project #
1P50AA022534-01
Application #
8600484
Study Section
Special Emphasis Panel (ZAA1-GG (50))
Project Start
Project End
Budget Start
2014-08-05
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$232,197
Indirect Cost
$78,424
Name
University of New Mexico Health Sciences Center
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Sanchez, Joshua J; Noor, Shahani; Davies, Suzy et al. (2017) Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function. J Neuroinflammation 14:254
Cunningham, Lee Anna; Newville, Jessie; Li, Lu et al. (2017) Prenatal Alcohol Exposure Leads to Enhanced Serine 9 Phosphorylation of Glycogen Synthase Kinase-3? (GSK-3?) in the Hippocampal Dentate Gyrus of Adult Mouse. Alcohol Clin Exp Res 41:1907-1916
Izquierdo, A; Brigman, J L; Radke, A K et al. (2017) The neural basis of reversal learning: An updated perspective. Neuroscience 345:12-26
BolaƱos, Alfredo D; Coffman, Brian A; Candelaria-Cook, Felicha T et al. (2017) Altered Neural Oscillations During Multisensory Integration in Adolescents with Fetal Alcohol Spectrum Disorder. Alcohol Clin Exp Res 41:2173-2184
Varaschin, Rafael K; Allen, Nyika A; Rosenberg, Martina J et al. (2017) Prenatal Alcohol Exposure Increases Histamine H3 Receptor-Mediated Inhibition of Glutamatergic Neurotransmission in Rat Dentate Gyrus. Alcohol Clin Exp Res :
Hamidovic, Ajna (2017) Targeting Mediators of Smoking Persistence with Intranasal Insulin. Front Pharmacol 8:706
Newville, Jessie; Valenzuela, Carlos Fernando; Li, Lu et al. (2017) Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder. Glia 65:1317-1332
Noor, Shahani; Sanchez, Joshua J; Vanderwall, Arden G et al. (2017) Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels. Brain Behav Immun 61:80-95
Marquardt, Kristin; Sigdel, Rahul; Brigman, Jonathan L (2017) Touch-screen visual reversal learning is mediated by value encoding and signal propagation in the orbitofrontal cortex. Neurobiol Learn Mem 139:179-188
Morton, Russell A; Valenzuela, C Fernando (2016) Further characterization of the effect of ethanol on voltage-gated Ca(2+) channel function in developing CA3 hippocampal pyramidal neurons. Brain Res 1633:19-26

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