The Neuropathology Core has been instrumental in providing support for establishing the accuracy of clinical diagnosis of Alzheimer's Disease (AD) and dementia with Lewy bodies (DLB), delineating structural and clinico-pathological correlates of dementia in AD, identifying new neuropathological entities causing dementia, provide tissues to investigators and helping to better understand the mechanisms of synaptic degeneration in AD. For the renewal the Aims of the Neuropathology Core will be to: 1) perform rapid autopsies and procure brains from the ADRC participants, using a standardized protocol;2) perform standardized neuropathological diagnoses of demented and normal aged (control) patients clinically evaluated by the UCSD ADRC;3) perform Braak staging and lesion counts for AD, DLB and fronto-temporal dementia (FTD) cases;4) maintain a state of the art brain repository to provide the ADRC projects and other investigators with well characterized;5) perform immunochemical analysis relevant to neurodegeneration and amyloid production in selected ADRC cases and 6) foster the utilization of the ADRC Neuropathology tissue repository for new research and inter-center collaborations. Approximately 40 cases and 20 tissue requests will be processed a year. The neuropathological results will be submitted to the National Alzheimer's Coordinating Committee (NACC) in compliance with NIA requirements. As part of the mission of the Core we will also continue to support extensive collaborations with national and international investigators and train fellows, residents, graduate and undergraduate students in neuropathology and microscopy techniques. We will be provide brain tissues and expert consultation on AD and DLB cases for Project 1, tissues and data relevant to axonal transport pathology in DLB to Project 2, and data on neurodegeneration of selected neuronal regions in DLB cases to Project 3. The Core also contributes significantly to the other Cores and is involved in developing new assays and incorporating new tools for neuropathological analysis including stereology and laser capture microscopy.

Public Health Relevance

AD affects millions of Americans with its risk growing exponentially with age. The AD Centers Program fosters research related to AD and non-AD dementias. The ADRC will enhance the performance of innovative research on AD and related topics, including research that may lead to potential disease modifying therapies or behavioral treatments. It will provide an environment and core resources to enhance research, foster professional and community training, and coordinate interdisciplinary research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005131-29
Application #
8375264
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
29
Fiscal Year
2012
Total Cost
$287,426
Indirect Cost
$63,755
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Zlatar, Zvinka Z; Muniz, Martha; Galasko, Douglas et al. (2017) Subjective Cognitive Decline Correlates With Depression Symptoms and Not With Concurrent Objective Cognition in a Clinic-Based Sample of Older Adults. J Gerontol B Psychol Sci Soc Sci :
Katsumata, Yuriko; Nelson, Peter T; Ellingson, Sally R et al. (2017) Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. Neurobiol Aging 53:193.e17-193.e25
Li, Ge; Shofer, Jane B; Petrie, Eric C et al. (2017) Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. Alzheimers Res Ther 9:48
Granholm, Eric L; Panizzon, Matthew S; Elman, Jeremy A et al. (2017) Pupillary Responses as a Biomarker of Early Risk for Alzheimer's Disease. J Alzheimers Dis 56:1419-1428
Cronin, Peter; McCarthy, Michael J; Lim, Andrew S P et al. (2017) Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement 13:689-700
Huang, Timothy Y; Zhao, Yingjun; Jiang, Lu-Lin et al. (2017) SORLA attenuates EphA4 signaling and amyloid ?-induced neurodegeneration. J Exp Med 214:3669-3685
Galasko, Douglas R; Shaw, Leslie M (2017) Alzheimer disease: CSF biomarkers for Alzheimer disease - approaching consensus. Nat Rev Neurol 13:131-132
Jacobs, Diane M; Ard, M Colin; Salmon, David P et al. (2017) Potential implications of practice effects in Alzheimer's disease prevention trials. Alzheimers Dement (N Y) 3:531-535
Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738

Showing the most recent 10 out of 854 publications