The Education and Information Core provides both training in basic science and clinical aspects of Alzheimer's disease (AD), and information transfer within the ADRC, to health professional in the community, to caregivers and individuals affected by the disease, and to the general public. This includes providing cutting edge research training, professional staff enrichment, fostering interest in AD especially in under- represented groups, and providing information about our ADRC and its clinical research programs. We will also reach out to caregivers and individuals affected by AD to provide them with information, support groups, access to community resources, and opportunities to participate in research. This Core, along with the Clinical Core, shares the primary responsibility for recruitment for our studies.
Five specific aims will accomplish these goals: 1) Provide professional training in clinical and research skills to academic and professional staff at UCSD and other universities in San Diego including physicians, researchers, graduate students, postdoctoral fellows, neuropsychologists, nurses, and social workers. 2) Maintain outreach programs to community healthcare professionals and families to enhance knowledge about AD diagnosis, care, and research and,in turn, enhance recruitment for ADRC-related research studies. Develop new programs and outreach as needed to ensure enrollment of special populations, such as patients with Dementia with Lewy bodies or Mild Cognitive Impairment. 3) Develop culturally sensitive strategies and programs for Hispanic elderly and healthcare professionals who serve the Hispanic community. Educate them regarding AD and related disorders and encourage participation in all aspects of clinical research. 4) Provide innovative social and educational support programs for persons with dementia and their caregivers. 5) Evaluate the success of all outreach, recruitment, and educational programs. Use the data from these evaluations to develop an annual needs assessment in conjunction with the Clinical Core, Project, and Pilot Principal Investigators.

Public Health Relevance

AD affects millions of Americans with its risk growing exponentially with age. The AD Centers Program fosters research related to AD and non-AD dementias. The ADRC will enhance the performance of innovative research on AD and related topics, including research that may lead to potential disease modifying therapies or behavioral treatments. It will provide an environment and core resources to enhance research, foster professional and community training, and coordinate interdisciplinary research.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Edmonds, Emily C; Delano-Wood, Lisa; Clark, Lindsay R et al. (2015) Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors. Alzheimers Dement 11:415-24
Dhungel, Nripesh; Eleuteri, Simona; Li, Ling-Bo et al. (2015) Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on ?-synuclein. Neuron 85:76-87
Bangen, Katherine J; Nation, Daniel A; Delano-Wood, Lisa et al. (2015) Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease. Alzheimers Dement 11:394-403.e1
Donohue, Michael C; Moghadam, Setareh H; Roe, Allyson D et al. (2015) Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement 11:1069-79
Edmonds, Emily C; Delano-Wood, Lisa; Galasko, Douglas R et al. (2014) Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. J Int Neuropsychol Soc 20:836-47
Overk, Cassia R; Masliah, Eliezer (2014) Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol 88:508-16
Yu, Peng; Sun, Jia; Wolz, Robin et al. (2014) Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging 35:808-18
Nuber, Silke; Tadros, Daniel; Fields, Jerel et al. (2014) Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol 127:477-94
Wang, Lina; Das, Utpal; Scott, David A et al. (2014) ?-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol 24:2319-26
Shi, Min; Liu, Changqin; Cook, Travis J et al. (2014) Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol 128:639-50

Showing the most recent 10 out of 484 publications