CORE C: DATA MANAGEMENT AND STATISTICAL - ABSTRACT The Data Management and Statistical Core provide statistical consulting, data management and information transfer resources to enhance the quality of Alzheimer's disease research conducted by the ADRC investigators.
The specific aims are: 1. To provide database support to the Cores and Projects. To coordinate the entry, quality control, management and analysis of data generated by the enrollment, evaluation, and follow up of outpatient and control subjects recruited by the Center's Clinical Core. Similarly, to coordinate the entry, quality control, management and analysis of data generated by the Center's Neuropathology Core and neuroimaging data generated by the Clinical Core and collaborating investigators. 2. To prepare the ADRC database for routine submission to the National Alzheimer's Coordinating Center (NACC), support new NACC procedures and initiatives, and resolve NACC queries. 3. To provide statistical design and analysis consultation services to ADRC investigators. Design consultation includes power calculations and statistical analysis planning. Data analysis support ranges from providing simple descriptive statistics to the conduct of complex multivariate statistical analyses. 4. To develop new statistical methodology focused on application to Alzheimer's disease data. 5. To educate investigators, trainees and junior faculty in the principles and use of statistical analysis methodologies.
|Edmonds, Emily C; Delano-Wood, Lisa; Clark, Lindsay R et al. (2015) Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors. Alzheimers Dement 11:415-24|
|Dhungel, Nripesh; Eleuteri, Simona; Li, Ling-Bo et al. (2015) Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on ?-synuclein. Neuron 85:76-87|
|Bangen, Katherine J; Nation, Daniel A; Delano-Wood, Lisa et al. (2015) Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease. Alzheimers Dement 11:394-403.e1|
|Donohue, Michael C; Moghadam, Setareh H; Roe, Allyson D et al. (2015) Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement 11:1069-79|
|Overk, Cassia R; Masliah, Eliezer (2014) Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol 88:508-16|
|Edmonds, Emily C; Delano-Wood, Lisa; Galasko, Douglas R et al. (2014) Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. J Int Neuropsychol Soc 20:836-47|
|Nuber, Silke; Tadros, Daniel; Fields, Jerel et al. (2014) Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol 127:477-94|
|Yu, Peng; Sun, Jia; Wolz, Robin et al. (2014) Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging 35:808-18|
|Wang, Lina; Das, Utpal; Scott, David A et al. (2014) ?-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol 24:2319-26|
|Shi, Min; Liu, Changqin; Cook, Travis J et al. (2014) Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol 128:639-50|
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