CORE F: HISPANIC SATELLITE - ABSTRACT There were about 46 million Hispanics in the USA in 2010. Elderly Hispanics are at risk for dementia, due to Alzheimer's Disease (AD) and vascular risk factors. The UCSD ADRC's studies of aging and dementia among Hispanics aim to improve our understanding of AD and related disorders and to overcome barriers to effective assessment, diagnosis and treatment of early (and even preclinical) disease. The Satellite will support general research in aging and dementia, because subjects will undergo the same procedures, including biomarker studies and request for autopsy consent, as non-Hispanic subjects in the ADRC, and will contribute to research projects and clinical trials. In addition, the Satellite will support research into aspects unique to Hispanics, including 1) the influence of bilingualism and low education on diagnostic assessment and in cognitive reserve and dementia risk;2) genetic, vascular, and socio-economic risk factors for cognitive decline and dementia. Overall aims for the Hispanic Satellite in this ADRC renewal application are to: 1) Support research efforts by recruiting and following well-characterized Hispanic subjects with normal cognition, Mild Cognitive Impairment (MCI), and AD. The Satellite will follow about 100 subjects (the balance between continued recruitment and death and dropout). Subjects will undergo standard clinical characterization (including the Uniform Data Set procedures). Biological samples (DNA, plasma and CSF), MRI and other brain images will be obtained. A comprehensive database will be maintained. Subjects will continue to contribute to autopsy studies after death. Data, biosamples and brain imaging studies from Hispanic Satellite subjects will be integrated with those from non-Hispanics followed by the Clinical Core. 2) Interact widely with researchers at UCSD, the VA Medical Center, and nearby research institutions. In particular, support ongoing funded research studies on bilingualism and on brain imaging and cognitive changes in aging in relation to APOE genotype and vascular risk factors. 4) Provide data to the National Alzheimer's Coordinating Center, and DNA to NCRAD, and collaborate with other AD Centers, and with multi-Center research efforts related to AD and dementia. Subjects will be offered participation in clinical trials organized by the Alzheimer's Disease Cooperative Study (ADCS), the Dominantly Inherited Alzheimer Network (DIAN), and by pharmaceutical companies. 5) Continue to support innovative research and train new investigators, 6) Foster professional education and training, and to improve public knowledge and awareness about aging, vascular and other risk factors that influence cognitive health in aging and dementia risk among Hispanics. To provide innovative support efforts for patients and families affected by AD.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Edmonds, Emily C; Delano-Wood, Lisa; Clark, Lindsay R et al. (2015) Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors. Alzheimers Dement 11:415-24
Dhungel, Nripesh; Eleuteri, Simona; Li, Ling-Bo et al. (2015) Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on ?-synuclein. Neuron 85:76-87
Bangen, Katherine J; Nation, Daniel A; Delano-Wood, Lisa et al. (2015) Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease. Alzheimers Dement 11:394-403.e1
Donohue, Michael C; Moghadam, Setareh H; Roe, Allyson D et al. (2015) Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement 11:1069-79
Edmonds, Emily C; Delano-Wood, Lisa; Galasko, Douglas R et al. (2014) Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. J Int Neuropsychol Soc 20:836-47
Overk, Cassia R; Masliah, Eliezer (2014) Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol 88:508-16
Yu, Peng; Sun, Jia; Wolz, Robin et al. (2014) Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging 35:808-18
Nuber, Silke; Tadros, Daniel; Fields, Jerel et al. (2014) Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol 127:477-94
Wang, Lina; Das, Utpal; Scott, David A et al. (2014) ?-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol 24:2319-26
Shi, Min; Liu, Changqin; Cook, Travis J et al. (2014) Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol 128:639-50

Showing the most recent 10 out of 484 publications