The underlying philosophy of the Core remains a belief that validation of diagnosis is critical to clinical research into neurodegenerative diseases and that tissue-based studies are a critical complement to in vitro studies of the biologic process that underlying these diseases. By providing these two pillars to the clinical and scientific community, the Neuropathology Core is able to make a contribution to the amelioration of suffering associated with AD and related disorders.
The Specific Aims of the Neuropathology Coreare: 1. To establish an accurate neuropathological diagnosis on all brains submitted with standardized reporting, including clinicopathological correlation and interpretation of findings, to the Clinical Core, other treating physicians andfamilies; 2. To maintain a source of brain tissue and other samples for investigators studying AD and related disorders, through preparation of tissue in a standardized manner, including determination of RNAquality, with special consideration of investigators within the Massachusetts ADRC; 3. To work with the Clinical Core to develop, store and distribute DNA, cell lines, plasma and serum collected under the Clinical Core's Biomarkers Initiative; 4. To train diagnostic and experimental neuropathologists in the neuropathology of dementing disorders; and 5. To participate in cooperative ventures with other groups studying neurodegenerative diseases, both human and animal models, including other Alzheimer Centers (ADRCs &ADCs), NACC, NINDS- supported Udall Center, as well as other consortia and individual investigators. These broad goals, which are in continuity with the historical activities of the Neuropathology Core, will enhance the value of the collected brain tissue to individual investigators whose specific research projects depend upon receiving carefully prepared and examined tissue.
Brain tissue is a critical resource for many important experiments that are defining the underlying pathology of Alzheimer disease and other neurodegenerative diseases. The ability to use the collect tissue in experiments is essential as new therapies and disease markers are developed.
|Ward, Andrew M; Mormino, Elizabeth C; Huijbers, Willem et al. (2015) Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiol Aging 36:265-72|
|Aganj, Iman; Reuter, Martin; Sabuncu, Mert R et al. (2015) Avoiding symmetry-breaking spatial non-uniformity in deformable image registration via a quasi-volume-preserving constraint. Neuroimage 106:238-51|
|Bickart, Kevin C; Brickhouse, Michael; Negreira, Alyson et al. (2014) Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale. J Neurol Neurosurg Psychiatry 85:438-48|
|Riascos, David; Nicholas, Alexander; Samaeekia, Ravand et al. (2014) Alterations of Ca²?-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiol Aging 35:1325-33|
|Papp, Kathryn V; Amariglio, Rebecca E; Dekhtyar, Maria et al. (2014) Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory. Clin Neuropsychol 28:771-85|
|Jackson, John W; Schneeweiss, Sebastian; VanderWeele, Tyler J et al. (2014) Quantifying the role of adverse events in the mortality difference between first and second-generation antipsychotics in older adults: systematic review and meta-synthesis. PLoS One 9:e105376|
|Schultz, Aaron P; Chhatwal, Jasmeer P; Huijbers, Willem et al. (2014) Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage 102 Pt 2:620-36|
|Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose et al. (2014) Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett 562:63-8|
|Mormino, Elizabeth C; Betensky, Rebecca A; Hedden, Trey et al. (2014) Amyloid and APOE ?4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology 82:1760-7|
|Stoub, Travis R; Detoledo-Morrell, Leyla; Dickerson, Bradford C (2014) Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults. Neurobiol Aging 35:1855-61|
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