The MADRC Administrative core provides infrastructural support and integrative activities for the many activities of the MADRC Cores, projects, affiliated programs, and local and national initiatives in which we participate. We provide the overall framework for Center activities, direct its programs, and provide a sense of Centerness by facilitating smooth interactions among the Center's Cores and Projects. The Core acts as the interface of the MADRC both internally within our institutions and externally for collaborative projects. The Administrative Core helps organize resources and harmonizes Alzheimer research related activities within our multi-institutional environment, as well as with the Alzheimer Association and other lay and community groups interested in Alzheimer disease and dementias.
Five aims encompass our mission: 1) First, leadership in the Core sets the tone and course of research within the Center. We ensure the integrity of our funded projects, and encourage and support new dementia related research initiatives by leveraging MADRC resources and infrastructure, attract new investigators to the field and support their efforts. 2) We recruit, identify and fund Pilot Projects targeted primarily at young investigators just establishing their research careers. We developed a successful collaboration with the Harvard Neurodiscovery Center's pilot program that allows us to increase the number of grantees;there is a common review system and a successful Pilot Awardee mentoring program. 3) The MADRC is an active participant in many national programs including NACC, ADCS, ADNI, DIAN, and ADGC studies, and the Administrative Core coordinates our involvement in these programs as well as providing leadership for many national and international Alzheimer related projects. Similarly, the Administrative Core is responsible for orchestrating interactions within the local environment, including the clinical operations in the MGH's Memory Disorder Unit and research programs in the Martinos Neuroimaging Center. 4) The Administrative Core is charged with establishing a formal External Scientific Advisory Board; we also have established an Internal Scientific Advisory Board enlisting some of the key institutional stakeholders and collaborators in Alzheimer research. 5) Finally, we provide administrative support with grants administration, financial responsibility, IRB interactions, organization of committees (including the Executive Committee of Core and Project leadership), assess needs, and balance distribution of resources aimed at achieving the Center's scientific goals: understanding the early phase of dementing illness as well as providing support for ongoing and collaborative studies in established dementia. Overall, the Administrative Core takes responsibility for ensuring Center responsiveness to new initiatives, and supports new research opportunities directed towards uncovering the etiology, pathogenic mechanisms, and ultimate cure or prevention of Alzheimer's and related disorders from the earliest phase.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
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Special Emphasis Panel (ZAG1-ZIJ-4 (J1))
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Massachusetts General Hospital
United States
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Ward, Andrew M; Mormino, Elizabeth C; Huijbers, Willem et al. (2015) Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiol Aging 36:265-72
Aganj, Iman; Reuter, Martin; Sabuncu, Mert R et al. (2015) Avoiding symmetry-breaking spatial non-uniformity in deformable image registration via a quasi-volume-preserving constraint. Neuroimage 106:238-51
Bickart, Kevin C; Brickhouse, Michael; Negreira, Alyson et al. (2014) Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale. J Neurol Neurosurg Psychiatry 85:438-48
Riascos, David; Nicholas, Alexander; Samaeekia, Ravand et al. (2014) Alterations of Ca²?-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiol Aging 35:1325-33
Papp, Kathryn V; Amariglio, Rebecca E; Dekhtyar, Maria et al. (2014) Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory. Clin Neuropsychol 28:771-85
Jackson, John W; Schneeweiss, Sebastian; VanderWeele, Tyler J et al. (2014) Quantifying the role of adverse events in the mortality difference between first and second-generation antipsychotics in older adults: systematic review and meta-synthesis. PLoS One 9:e105376
Schultz, Aaron P; Chhatwal, Jasmeer P; Huijbers, Willem et al. (2014) Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage 102 Pt 2:620-36
Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose et al. (2014) Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett 562:63-8
Mormino, Elizabeth C; Betensky, Rebecca A; Hedden, Trey et al. (2014) Amyloid and APOE ?4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology 82:1760-7
Stoub, Travis R; Detoledo-Morrell, Leyla; Dickerson, Bradford C (2014) Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults. Neurobiol Aging 35:1855-61

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