The primary objective of the Data core is to provide data management and biostatistical support to the Cores and Projects of the University of Washington Alzheimer's Disease Research Center (UWADRC).
Our specific aims are: (1) To provide database management support to projects, cores, and pilot projects;(2) to provide support to projects, cores, pilot projects and other users of the ADRC resources in the areas of statistical design and analysis;(3) To assist projects, cores, and pilot projects In manuscript preparation relating to statistical analysis and interpretation;(4) To maintain a proactive approach to provision of such support;and (5) To evaluate, develop, extend, and apply appropriate statistical methodologies for problems arising out of projects, cores, and pilot projects;and (6) To maintain the computing environment needed to achieve aims 1, 2, and 5. The Data Core computer and data management specialists construct, modify, and maintain the databases needed to store and access the UWADRC data for the cores and projects, and for extracting data for submission to the National Alzheimer's disease Coordinating Center. Our computer specialists also maintain the computer hardware and the systems level software needed for access to the computers and databases via the internet, while at the same time keeping the computer systems up-to-date In terms of security, to prevent unauthorized access. The computer specialists and research consultants are also available to provide some programming services, as needed, to cores and projects. Data Core biostatistlcians are available to all Cores, Projects, and Pilot Projects for consultation and assistance regarding statistical design, analysis, and interpretation of data, as well as preparation of manuscripts that use such approaches. This includes evaluation, extension, and development of new analytical methodology, implementation and extension of software, as needed, and the authoring and co-authoring of manuscripts based on such new, modified, or evaluated methods. The activities of Data Core members towards these goals will facilitate the overall goals of the UWADRC in its mission toward reducing the burden of Alzheimer's disease.

Public Health Relevance

The Data Core of the University of Washington Alzheimer's Disease Research Center (UW ADRC) will provide the necessary data management assistance needed to efficiently and accurately store the data collected by the Center. It will also facilitate the translation of data to scientific discoveries relevant to the prevention, treatment or diagnosis of Alzheimer's disease through assistance with statistical data analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005136-31
Application #
8668840
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-20
Toledo, Jon B; Gopal, Pallavi; Raible, Kevin et al. (2016) Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathol 131:393-409
Ringman, John M; Monsell, Sarah; Ng, Denise W et al. (2016) Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol 75:284-90
Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2016) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement :
Besser, Lilah M; Alosco, Michael L; Ramirez Gomez, Liliana et al. (2016) Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol 75:955-962
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2016) Neuropsychiatric symptoms and Apolipoprotein E: Associations with eventual Alzheimer's disease development. Arch Gerontol Geriatr 65:231-8
Crane, Paul K; Gibbons, Laura E; McCurry, Susan M et al. (2016) Importance of home study visit capacity in dementia studies. Alzheimers Dement 12:419-26
Henderson, Benjamin W; Gentry, Erik G; Rush, Travis et al. (2016) Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. J Neurochem 138:525-31
Beckelman, Brenna C; Zhou, Xueyan; Keene, C Dirk et al. (2016) Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease. Neurodegener Dis 16:39-43
John, Samantha E; Gurnani, Ashita S; Bussell, Cara et al. (2016) The effectiveness and unique contribution of neuropsychological tests and the δ latent phenotype in the differential diagnosis of dementia in the uniform data set. Neuropsychology 30:946-960

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