The primary objective of the Data core is to provide data management and biostatistical support to the Cores and Projects of the University of Washington Alzheimer's Disease Research Center (UWADRC).
Our specific aims are: (1) To provide database management support to projects, cores, and pilot projects;(2) to provide support to projects, cores, pilot projects and other users of the ADRC resources in the areas of statistical design and analysis;(3) To assist projects, cores, and pilot projects In manuscript preparation relating to statistical analysis and interpretation;(4) To maintain a proactive approach to provision of such support;and (5) To evaluate, develop, extend, and apply appropriate statistical methodologies for problems arising out of projects, cores, and pilot projects;and (6) To maintain the computing environment needed to achieve aims 1, 2, and 5. The Data Core computer and data management specialists construct, modify, and maintain the databases needed to store and access the UWADRC data for the cores and projects, and for extracting data for submission to the National Alzheimer's disease Coordinating Center. Our computer specialists also maintain the computer hardware and the systems level software needed for access to the computers and databases via the internet, while at the same time keeping the computer systems up-to-date In terms of security, to prevent unauthorized access. The computer specialists and research consultants are also available to provide some programming services, as needed, to cores and projects. Data Core biostatistlcians are available to all Cores, Projects, and Pilot Projects for consultation and assistance regarding statistical design, analysis, and interpretation of data, as well as preparation of manuscripts that use such approaches. This includes evaluation, extension, and development of new analytical methodology, implementation and extension of software, as needed, and the authoring and co-authoring of manuscripts based on such new, modified, or evaluated methods. The activities of Data Core members towards these goals will facilitate the overall goals of the UWADRC in its mission toward reducing the burden of Alzheimer's disease.
The Data Core of the University of Washington Alzheimer's Disease Research Center (UW ADRC) will provide the necessary data management assistance needed to efficiently and accurately store the data collected by the Center. It will also facilitate the translation of data to scientific discoveries relevant to the prevention, treatment or diagnosis of Alzheimer's disease through assistance with statistical data analysis.
|Postupna, Nadia; Latimer, Caitlin S; Larson, Eric B et al. (2017) Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ?4. Am J Pathol 187:884-895|
|Sposato, Luciano A; Ruíz Vargas, Estefanía; Riccio, Patricia M et al. (2017) Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimers Dement 13:770-777|
|Qian, Jing; Hyman, Bradley T; Betensky, Rebecca A (2017) Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. JAMA Neurol 74:540-548|
|Burke, Shanna L; O'Driscoll, Janice; Alcide, Amary et al. (2017) Moderating risk of Alzheimer's disease through the use of anxiolytic agents. Int J Geriatr Psychiatry 32:1312-1321|
|Moga, Daniela C; Taipale, Heidi; Tolppanen, Anna-Maija et al. (2017) A Comparison of Sex Differences in Psychotropic Medication Use in Older People with Alzheimer's Disease in the US and Finland. Drugs Aging 34:55-65|
|Bettcher, Brianne M; Ard, M Colin; Reed, Bruce R et al. (2017) Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. J Alzheimers Dis 59:1307-1315|
|Devanand, Davangere P; Liu, Xinhua; Brown, Patrick J (2017) Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia. Alzheimer Dis Assoc Disord 31:55-61|
|Boord, Peter; Madhyastha, Tara M; Askren, Mary K et al. (2017) Executive attention networks show altered relationship with default mode network in PD. Neuroimage Clin 13:1-8|
|LoBue, Christian; Wadsworth, Hannah; Wilmoth, Kristin et al. (2017) Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease. Clin Neuropsychol 31:85-98|
|Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204|
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