In response to the 2009 RFA, the primary focus of the UWADRC Education and Information Core (El Core) is to recruit and retain research subjects, in coordination with the Clinical Core, The El Core has three Specific Aims:
Specific Aim 1. To promote the recruitment and retention of research subjects.
Specific Aim 2. To promote the recruitment and retention of subjects from the African American minority community.
Specific Aim 3. To promote community and professional outreach and education programs. To achieve these aims the El Core will be the public face of the UW ADRC using lay and professional outreach programs and education to increase the exposure of the center. For this funding cycle the El Core has several new efforts. The El Core has established a formal agreement with the Alzheimer's Association of Western and Central Washington to collaborate on a large annual conference, a minority caregiver forum, and several regional research recruitment programs. These collaborations will substantially increase our public exposure and promote greater cooperation between the UW ADRC and the Alzheimer's Association. The El Core has also now established a Minority Advisory Board composed of local African Americans with extensive community ties and expertise In aging and AD. This board will serve as a critical advisor to the El Core and establish a formal plan to Improve on minority recruitment Into the UW ADRC and ADRC-affiliated clinical research studies. In addition, the board members will be important liaison between the UWADRC and the African American community. The El Core will continue the many other highly successful lay and professional outreach and educational programs. In summary, the El Core will continue to be an important community resource and liaison for the UWADRC. We believe our new alms will enhance the research efforts of the UWADRC through improved recruitment and retention of research subjects, including African Americans.

Public Health Relevance

AD remains an impending public health crisis with no very effective treatments, no cure, and no prevention. This application responds to the need for increased knowledge in AD so that effective treatments can be developed.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
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Special Emphasis Panel (ZAG1)
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University of Washington
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Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-20
Toledo, Jon B; Gopal, Pallavi; Raible, Kevin et al. (2016) Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathol 131:393-409
Ringman, John M; Monsell, Sarah; Ng, Denise W et al. (2016) Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol 75:284-90
Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2016) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement :
Besser, Lilah M; Alosco, Michael L; Ramirez Gomez, Liliana et al. (2016) Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol 75:955-962
Crane, Paul K; Gibbons, Laura E; McCurry, Susan M et al. (2016) Importance of home study visit capacity in dementia studies. Alzheimers Dement 12:419-26
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2016) Neuropsychiatric symptoms and Apolipoprotein E: Associations with eventual Alzheimer's disease development. Arch Gerontol Geriatr 65:231-8
Beckelman, Brenna C; Zhou, Xueyan; Keene, C Dirk et al. (2016) Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease. Neurodegener Dis 16:39-43
Henderson, Benjamin W; Gentry, Erik G; Rush, Travis et al. (2016) Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. J Neurochem 138:525-31
Tosto, Giuseppe; Monsell, Sarah E; Hawes, Stephen E et al. (2016) Progression of Extrapyramidal Signs in Alzheimer's Disease: Clinical and Neuropathological Correlates. J Alzheimers Dis 49:1085-93

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