The purpose of the Administrative Core is to establish the research agenda for the ADRC and to insure the optimal utilization of Center resources by maximizing institutional strengths in the service of broadening knowledge about diagnosis, management, treatment, and prevention of AD and other dementias through basic and applied research.
The specific aims are to 1) Provide the leadership to facilitate the overall research goals of the ADRC. 2) Coordinate and integrate ADRC activities ensuring that the Cores meet the needs of the Projects and that the Projects are utilizing the Cores. 3)Foster growth of new research initiatives and recruit new researchers through the pilot program and through other institutional resources. 4) Ensure future growth for the ADRC. This includes maintaining a proper balance of faculty and staff renewal in order to insure that our clinical and other core operations are accomplished and also setting future directions and optimizing resources available to Insure that our research efforts grow. 5) Facilitate communication: (a) with NACC to insure timely transmission of data sets;(b) with other ADCs to maximize collaboration;and (c) with NIA program staff including coordination with NIA on media coverage and dissemination of Important findings. 6) Facilitate interaction with the Alzheimer's Disease Cooperative Study and other clinical trial organizations. 7) Provide administrative oversight. This includes developing and maintaining budgets and ensuring that funds are utilized to conduct and enhance Core and scientific activities. The Core functions are managed through routine meetings and reporting and auditing routines. The leadership of the Core is advised by both internal and external advisory boards.

Public Health Relevance

The Administration Core functions to insure commitment to cutting edge science that will lead to early diagnosis, better treatments, and, ultimately, prevention of Alzheimer's disease and other cognitive disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005138-30
Application #
8662600
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
30
Fiscal Year
2014
Total Cost
$249,061
Indirect Cost
$90,416
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204
Tripodis, Yorghos; Alosco, Michael L; Zirogiannis, Nikolaos et al. (2017) The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer's Disease Dementia. J Alzheimers Dis 59:251-263
Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2017) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement 13:654-662
Jutkowitz, Eric; Kane, Robert L; Gaugler, Joseph E et al. (2017) Societal and Family Lifetime Cost of Dementia: Implications for Policy. J Am Geriatr Soc 65:2169-2175
Livny, Abigail; Ravona-Springer, Ramit; Heymann, Anthony et al. (2017) Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes. Diabetes 66:2927-2932
Moheb, Negar; Mendez, Mario F; Kremen, Sarah A et al. (2017) Executive Dysfunction and Behavioral Symptoms Are Associated with Deficits in Instrumental Activities of Daily Living in Frontotemporal Dementia. Dement Geriatr Cogn Disord 43:89-99
Monsell, Sarah E; Mock, Charles; Fardo, David W et al. (2017) Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. Alzheimer Dis Assoc Disord 31:232-238
Jiang, Yan; Loh, Yong-Hwee Eddie; Rajarajan, Prashanth et al. (2017) The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nat Genet 49:1239-1250
Kaur, G; Pawlik, M; Gandy, S E et al. (2017) Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Mol Psychiatry 22:981-989
Mez, Jesse; Chung, Jaeyoon; Jun, Gyungah et al. (2017) Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement 13:119-129

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