Abstract

This renewal of AG-05142 proposes an Alzheimer Disease Research Center (ADRC) program seated at USC with 4 aims and 4 new projects.
Aim 1 : Identify molecular and cellular mechanisms of neurodegeneration during D and normal aging processes.
Aim 2 : Develop hormonal interventions into age-related cognitive changes with clinical studies and animal models.
Aim 3 : Develop cognitive & imaging techniques to monitor aging, AD, & clinical interventions.
Aim 4 : Increase participation of Hispanic, African-American, and other minorities in drug trials. The USC-ADRC is comprised of the required cores and two special-service cores*: Clinical Core: Dir., Victor Henderson; co-Dir. Lon Schneider (Pharmacology Program). Minority Diagnosis and Treatment Satellite*, Dr. Helena Chui. Neuroimaging Core*, Dr. Manbir Singh. Neuropathology Core, Dir. Carol Miller. Education Information Transfer Core, Dir, Bob Knight. These cores serve four new projects of USC faculty: Proj. Alzheimer-like pathology in inclusion-body myopathy (Valerie Askanas). Proj. Choroid plexus in Abeta/apolipoprotein CNS homeostasis (Berislav Zlokovic). Proj. Aberrant DNA synthesis in dividing and non-dividing cells (Myron Goodman). Proj. fMRI studies of working memory, estrogen, & aging (MaryEllen MacDonald and Manbir Singh). The Cores also support a collaborative longitudinal study with Kaiser Permanente: Alzheimer disease & estrogen replacement; Galen Buckwater, co-PI) and two NIA program projects: Models of estrogen interactions with AD and The aging brain: vasculature, ischemia, & behavior. Genotypes of human subjects are obtained through the Molecular Biology Core of the NIEHS enter (John Peters, Dir.) Other users of these resources includes >40 federally funded USC faculty (Schools of Medicine; of Pharmacy; of Gerontology of Letters, Arts, & Sciences; and of Engineering), as well as >20 non-USC researchers. Collaborations with ADRCs of UCLA, UC Irvine, UC San Diego, Boston U, Columbia, Emory, Washington U, U Washington. These approaches to AD build on AD build on USC's long-standing commitment to research and education on aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005142-16S2
Application #
6084773
Study Section
Special Emphasis Panel (ZAG1 (J5))
Project Start
1984-09-28
Project End
2004-03-31
Budget Start
1999-07-01
Budget End
2000-03-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Miscellaneous
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Petok, Jessica R; Myers, Catherine E; Pa, Judy et al. (2018) Impairment of memory generalization in preclinical autosomal dominant Alzheimer's disease mutation carriers. Neurobiol Aging 65:149-157
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Weissberger, Gali H; Nation, Daniel A; Nguyen, Caroline P et al. (2018) Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans. Neurosci Biobehav Rev 94:49-58
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Wang, Junyan; Aydogan, Dogu Baran; Varma, Rohit et al. (2018) Modeling topographic regularity in structural brain connectivity with application to tractogram filtering. Neuroimage 183:87-98

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