The mission of the USC ADRC is to Reduce Alzheimer and Vascular Contributions to Cognitive Impairment in Diverse Populations. Our population cohorts include Caucasians ((Long Beach Longitudinal Study), Latino Americans (Los Angeles Latino Eye Study), and Asian Americans (Chinese American Eye Study). We work closely with other major programs at USC on atherosclerosis, including two program projects (The Aging Brain: Vasculature, H Chui PI;Progesterone in Brain Aging and AD, R Brinton, PI) Our philosophy is to recruit outstanding USC faculty to initiate innovative research that will be successful in garnering external funding. Key strategies include: 1) offering resources through our Cores (e.g., human subjects, tissues, and expertise), 2) annual research conference, and 3) pilot projects. The ADRC comprise 6 Cores (Administration, Data, Clinical, Education, Pathology, and Imaging) and 3 Projects: Zelinski (Course of Cognitive Change in Late Adulthood), Brinton/Pike (Novel NeuroSERMs and NeuroSARMs for protection against Alzheimer pathology), and Zheng (Cognitive Impairment in a Chinese American Community).
The Specific Aims of the Administrative Core are to: 1) Promote basic and clinical research at USC to reduce Alzheimer and vascular contributions to cognitive impairment in diverse populations, 2) Sponsor Joint Research Symposia with the EIT Core, including biannual Finch Symposium, 3) Solicit and select pilot projects consonant with the center them to promote the development of new grants, 4) Actively participate in collaborative and national research initiatives (including NACC, ADCS, ADNI, and GWAS) and resource sharing, 5) Guide appropriate and optimal utilization of Center Resources and Funding, 6) Seek annual oversight/advice from External and Internal Advisory Committees, and 7) Assist in protection of human subjects in research and facilitate submissions to the Institutional Review Board (IRB).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-29
Application #
8450806
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
29
Fiscal Year
2013
Total Cost
$246,037
Indirect Cost
$96,497
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Kammen, Alexandra; Law, Meng; Tjan, Bosco S et al. (2016) Automated retinofugal visual pathway reconstruction with multi-shell HARDI and FOD-based analysis. Neuroimage 125:767-79
Soosman, Steffan K; Joseph-Mathurin, Nelly; Braskie, Meredith N et al. (2016) Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging 47:201-209
Barnes, Samuel R; Ng, Thomas S C; Montagne, Axel et al. (2016) Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med 75:1967-77
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-9
Kennedy, Richard E; Cutter, Gary R; Wang, Guoqiao et al. (2016) Post Hoc Analyses of ApoE Genotype-Defined Subgroups in Clinical Trials. J Alzheimers Dis 50:1205-15
Crawford, Karen L; Neu, Scott C; Toga, Arthur W (2016) The Image and Data Archive at the Laboratory of Neuro Imaging. Neuroimage 124:1080-3
Finch, Caleb E; Shams, Sara (2016) Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice. Trends Neurosci 39:625-37
Halliday, Matthew R; Rege, Sanket V; Ma, Qingyi et al. (2016) Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab 36:216-27
Bilousova, Tina; Miller, Carol A; Poon, Wayne W et al. (2016) Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol 186:185-98

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