The Education and Information Core has two specific aims: (1) recruitment and retention. We will recruit and retain participants for specific research protocols and clinical trials, with a special emphasis on minorities and other underserved populations, particularly Latino populations. The recruitment and retention strategy was developed and is overseen in conjunction with the Clinical Core. The specific activities are designed to reflect best culturally informed practices. (2) education. Consistent with the overall focus of the ADRC on Reducing Alzheimer and Vascular Contributions to Cognitive Impairment in Diverse Populations, the EIC will communicate information and research findings about: (a) cognitive and behavioral changes that might signal onset of cognitive impairment or dementia, (b) importance of early diagnosis, (c) risk factors for dementia, and (d) behavioral changes that might reduce risk and protect cognitive health in old age. Vehicles for education include community presentations, our website, newsletter, press releases, and the Many Faces of Dementia conference series. Due to the prevalence of vascular risk factors in Latino communities, a major focus of education will be reducing vascular risks. Information will be tailored to what we have learned about perceptions of dementia in diverse populations. Input into recruitment and retention strategies and best approaches to education will be sought from individuals associated with prominent Latino organizations who will serve as community advisors. New initiatives in this application include: developing and maintaining a local registry of potential study volunteers-with and without cognitive impairment-who are not yet enrolled as ADRC participants;piloting a USC Memory and Aging Center Ambassador program to involve early stage patients, family, USC alumni, USC emeriti in promoting the value of research participation;hosting an annual gathering of research participants;developing a Spanish/English foto-novela for use in community education in refuting myths about dementia and encouraging earlier referral.

Public Health Relevance

to public health lies in faciliating participation in research leading to new knowledge about the causes and cure of dementia and in disseminating known behavioral changes that can reduce the burden of cognitive impairment and dementia that is associated with modifiable risk factors. The focus on Latinos responds to the increased number of Latino elderly and projected dementia cases in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-29
Application #
8450813
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
29
Fiscal Year
2013
Total Cost
$174,944
Indirect Cost
$68,614
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Kammen, Alexandra; Law, Meng; Tjan, Bosco S et al. (2016) Automated retinofugal visual pathway reconstruction with multi-shell HARDI and FOD-based analysis. Neuroimage 125:767-79
Soosman, Steffan K; Joseph-Mathurin, Nelly; Braskie, Meredith N et al. (2016) Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging 47:201-209
Barnes, Samuel R; Ng, Thomas S C; Montagne, Axel et al. (2016) Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med 75:1967-77
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-9
Kennedy, Richard E; Cutter, Gary R; Wang, Guoqiao et al. (2016) Post Hoc Analyses of ApoE Genotype-Defined Subgroups in Clinical Trials. J Alzheimers Dis 50:1205-15
Crawford, Karen L; Neu, Scott C; Toga, Arthur W (2016) The Image and Data Archive at the Laboratory of Neuro Imaging. Neuroimage 124:1080-3
Finch, Caleb E; Shams, Sara (2016) Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice. Trends Neurosci 39:625-37
Halliday, Matthew R; Rege, Sanket V; Ma, Qingyi et al. (2016) Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab 36:216-27
Bilousova, Tina; Miller, Carol A; Poon, Wayne W et al. (2016) Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol 186:185-98

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