The Education and Information Core has two specific aims: (1) recruitment and retention. We will recruit and retain participants for specific research protocols and clinical trials, with a special emphasis on minorities and other underserved populations, particularly Latino populations. The recruitment and retention strategy was developed and is overseen in conjunction with the Clinical Core. The specific activities are designed to reflect best culturally informed practices. (2) education. Consistent with the overall focus of the ADRC on Reducing Alzheimer and Vascular Contributions to Cognitive Impairment in Diverse Populations, the EIC will communicate information and research findings about: (a) cognitive and behavioral changes that might signal onset of cognitive impairment or dementia, (b) importance of early diagnosis, (c) risk factors for dementia, and (d) behavioral changes that might reduce risk and protect cognitive health in old age. Vehicles for education include community presentations, our website, newsletter, press releases, and the Many Faces of Dementia conference series. Due to the prevalence of vascular risk factors in Latino communities, a major focus of education will be reducing vascular risks. Information will be tailored to what we have learned about perceptions of dementia in diverse populations. Input into recruitment and retention strategies and best approaches to education will be sought from individuals associated with prominent Latino organizations who will serve as community advisors. New initiatives in this application include: developing and maintaining a local registry of potential study volunteers-with and without cognitive impairment-who are not yet enrolled as ADRC participants;piloting a USC Memory and Aging Center Ambassador program to involve early stage patients, family, USC alumni, USC emeriti in promoting the value of research participation;hosting an annual gathering of research participants;developing a Spanish/English foto-novela for use in community education in refuting myths about dementia and encouraging earlier referral.

Public Health Relevance

to public health lies in faciliating participation in research leading to new knowledge about the causes and cure of dementia and in disseminating known behavioral changes that can reduce the burden of cognitive impairment and dementia that is associated with modifiable risk factors. The focus on Latinos responds to the increased number of Latino elderly and projected dementia cases in this population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Schneider, L S; Mangialasche, F; Andreasen, N et al. (2014) Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014. J Intern Med 275:251-83
Gatto, Nicole M; Henderson, Victor W; Hodis, Howard N et al. (2014) Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles. Neurotoxicology 40:1-7
Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Villeneuve, Sylvia; Reed, Bruce R; Wirth, Miranka et al. (2014) Cortical thickness mediates the effect of ?-amyloid on episodic memory. Neurology 82:761-7
Porsteinsson, Anton P; Drye, Lea T; Pollock, Bruce G et al. (2014) Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 311:682-91
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606
Schneider, Lon S (2014) Rethinking the Food and Drug Administration's 2013 guidance on developing drugs for early-stage Alzheimer's disease. Alzheimers Dement 10:247-50
Escott-Price, Valentina; Bellenguez, Céline; Wang, Li-San et al. (2014) Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One 9:e94661
Cuajungco, Math P; Basilio, Luigi C; Silva, Joshua et al. (2014) Cellular zinc levels are modulated by TRPML1-TMEM163 interaction. Traffic 15:1247-65
Jayaraman, Anusha; Christensen, Amy; Moser, V Alexandra et al. (2014) Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology 155:1398-406

Showing the most recent 10 out of 253 publications