The USC ADRC focuses on reducing Alzheimer and vascular contributions to cognitive Impairment in diverse populations. Personnel of the Data Management and Statistics core provide particular expertise and collaborative experience in relation to overall ADRC objectives. The USC ADRC Data Management and Statistics Core collaborates with Administrative, Clinical, Pathology, Neuroimaging and Education Cores to provide database design, data collection and data management services. Biostatistical services include consultation with core directors, project directors, pilot study investigators and participating ADRC investigators regarding study designs, development of data sets and analytic plans, as well as direct analysis of ADRC-related data. Data management services include database systems design and maintenance, data entry and management of UDS, NACC Neuropathology, and other ADRC data, and interactions with NACC on issues related to data systems, uploading and retrieval of data, and responses to data queries. The overall objective of the Data Management and Statistics Core is to provide high quality data management and statistical consulting to the research projects and the cores of the ADRC, as accomplished by the following aims: 1. To maintain a Web-based data management system. 2. To train and work with staff of the Administrative, Clinical, Pathology, and Education Cores to ensure timely and accurate data entry and management 3. To work with the NACC to provide timely and complete submission of local UDS and Neuropathology data. 4. To provide data reports to core staff and investigators on a routine and as needed basis. 5. To provide biostatistical consulting to individual ADRC investigators in the design, coordination, and analyses of ADRC-related projects, including pilot projects.

Public Health Relevance

The Data Management and Statistics Core provides consulting on and provision of data coordination and biostatistical services to promote and optimize the research of the USC ADRC. Provision of accurate and reliable database support, development of valid study designs, and appropriate analysis of resulting data are fundamental to the completion of valid research.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Schneider, L S; Mangialasche, F; Andreasen, N et al. (2014) Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014. J Intern Med 275:251-83
Gatto, Nicole M; Henderson, Victor W; Hodis, Howard N et al. (2014) Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles. Neurotoxicology 40:1-7
Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Villeneuve, Sylvia; Reed, Bruce R; Wirth, Miranka et al. (2014) Cortical thickness mediates the effect of ?-amyloid on episodic memory. Neurology 82:761-7
Porsteinsson, Anton P; Drye, Lea T; Pollock, Bruce G et al. (2014) Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 311:682-91
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606
Schneider, Lon S (2014) Rethinking the Food and Drug Administration's 2013 guidance on developing drugs for early-stage Alzheimer's disease. Alzheimers Dement 10:247-50
Escott-Price, Valentina; Bellenguez, Céline; Wang, Li-San et al. (2014) Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One 9:e94661
Cuajungco, Math P; Basilio, Luigi C; Silva, Joshua et al. (2014) Cellular zinc levels are modulated by TRPML1-TMEM163 interaction. Traffic 15:1247-65
Jayaraman, Anusha; Christensen, Amy; Moser, V Alexandra et al. (2014) Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology 155:1398-406

Showing the most recent 10 out of 253 publications