The USC ADRC focuses on reducing Alzheimer and vascular contributions to cognitive Impairment in diverse populations. Personnel of the Data Management and Statistics core provide particular expertise and collaborative experience in relation to overall ADRC objectives. The USC ADRC Data Management and Statistics Core collaborates with Administrative, Clinical, Pathology, Neuroimaging and Education Cores to provide database design, data collection and data management services. Biostatistical services include consultation with core directors, project directors, pilot study investigators and participating ADRC investigators regarding study designs, development of data sets and analytic plans, as well as direct analysis of ADRC-related data. Data management services include database systems design and maintenance, data entry and management of UDS, NACC Neuropathology, and other ADRC data, and interactions with NACC on issues related to data systems, uploading and retrieval of data, and responses to data queries. The overall objective of the Data Management and Statistics Core is to provide high quality data management and statistical consulting to the research projects and the cores of the ADRC, as accomplished by the following aims: 1. To maintain a Web-based data management system. 2. To train and work with staff of the Administrative, Clinical, Pathology, and Education Cores to ensure timely and accurate data entry and management 3. To work with the NACC to provide timely and complete submission of local UDS and Neuropathology data. 4. To provide data reports to core staff and investigators on a routine and as needed basis. 5. To provide biostatistical consulting to individual ADRC investigators in the design, coordination, and analyses of ADRC-related projects, including pilot projects.

Public Health Relevance

The Data Management and Statistics Core provides consulting on and provision of data coordination and biostatistical services to promote and optimize the research of the USC ADRC. Provision of accurate and reliable database support, development of valid study designs, and appropriate analysis of resulting data are fundamental to the completion of valid research.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Kammen, Alexandra; Law, Meng; Tjan, Bosco S et al. (2016) Automated retinofugal visual pathway reconstruction with multi-shell HARDI and FOD-based analysis. Neuroimage 125:767-79
Soosman, Steffan K; Joseph-Mathurin, Nelly; Braskie, Meredith N et al. (2016) Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging 47:201-209
Barnes, Samuel R; Ng, Thomas S C; Montagne, Axel et al. (2016) Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med 75:1967-77
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-9
Kennedy, Richard E; Cutter, Gary R; Wang, Guoqiao et al. (2016) Post Hoc Analyses of ApoE Genotype-Defined Subgroups in Clinical Trials. J Alzheimers Dis 50:1205-15
Crawford, Karen L; Neu, Scott C; Toga, Arthur W (2016) The Image and Data Archive at the Laboratory of Neuro Imaging. Neuroimage 124:1080-3
Finch, Caleb E; Shams, Sara (2016) Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice. Trends Neurosci 39:625-37
Halliday, Matthew R; Rege, Sanket V; Ma, Qingyi et al. (2016) Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab 36:216-27
Bilousova, Tina; Miller, Carol A; Poon, Wayne W et al. (2016) Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol 186:185-98

Showing the most recent 10 out of 394 publications