The mission ofthe neuroimaging core is to facilitate funcfional and structural neuroimaging by ADRC investigators, to develop and maintain a neuroimaging database and to educate investigators on the potential of structural/functional neuroimaging in AD research.
The specific aims are: (1) Provide imaging data acquisition and processing for ADRC Project 1: The Course of Cognitive Change in Late Adulthood (Zelinski) and Project 3: Mild Cognitive Impairment in a Chinese- American Community (Zheng). (2) Provide technical support to investigators for pilot neuroimaging studies on a wide range of topics covering structural imaging, arterial spin-labeled (ASL) perfusion imaging, diffusion tensor imaging (DTI), funcfional magnefic resonance imaging (fMRI), voxel-based image analysis, and multimodality image co-registrafion. (3) Implement a web-based imaging database to archive and retrieve neuroimages and associated information acquired by ADRC investigators at USC and related sites, and (4) facilitate access to various imaging centers at USC including the new NIH funded 3T Research Resource located within the Department of Radiology at USC. The neuroimaging core has developed key technology in spatiotemporal fMRI and DTI tractography including normalization and quantificafion of tracts through white matter. During the past 5 years, the core supported 12 projects and pilots with the design of structural and functional imaging protocols including data acquisition, image processing and data analyses. The core also played a major role in successfully obtaining a High End Instrumentation grant from NCRR to establish a 3T research MRI facility at USC.

Public Health Relevance

Neuroimaging of the brain can offer early detection of Alzheimer and cerebrovascular disease. The Neuroimaging Core will assist Project 1 in differentiating different types of cognitive decline in elderly persons. It will assist Project 3 in determining whether decreased retinal blood flow can provide a screening tool for cerebrovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-30
Application #
8662616
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
30
Fiscal Year
2014
Total Cost
$90,957
Indirect Cost
$34,810
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Schneider, L S; Mangialasche, F; Andreasen, N et al. (2014) Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014. J Intern Med 275:251-83
Gatto, Nicole M; Henderson, Victor W; Hodis, Howard N et al. (2014) Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles. Neurotoxicology 40:1-7
Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Villeneuve, Sylvia; Reed, Bruce R; Wirth, Miranka et al. (2014) Cortical thickness mediates the effect of ?-amyloid on episodic memory. Neurology 82:761-7
Porsteinsson, Anton P; Drye, Lea T; Pollock, Bruce G et al. (2014) Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 311:682-91
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606
Schneider, Lon S (2014) Rethinking the Food and Drug Administration's 2013 guidance on developing drugs for early-stage Alzheimer's disease. Alzheimers Dement 10:247-50
Escott-Price, Valentina; Bellenguez, Céline; Wang, Li-San et al. (2014) Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One 9:e94661
Cuajungco, Math P; Basilio, Luigi C; Silva, Joshua et al. (2014) Cellular zinc levels are modulated by TRPML1-TMEM163 interaction. Traffic 15:1247-65
Jayaraman, Anusha; Christensen, Amy; Moser, V Alexandra et al. (2014) Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology 155:1398-406

Showing the most recent 10 out of 253 publications