Abstract

IMAGING CORE The Imaging Core has been significantly strengthened by the recruitments of Arthur Toga, Paul Thompson (INI- Institute for Neuroimaging and Informatics) and Berislav Zlokovic (ZNI-ZIlkha Neurogenetics Institute). Additionally on the pre-clinical side, further institutional support for the ADRC comes with the recruitments of Scott Fraser and Russell Jacobs. Together, these transformational recruits will strengthen the primary mission of the ADRC and its Imaging Core, which is to provide state of the art pre-clinical and clinical imaging acquisition, informatics/image repository and image analysis to this ADRC and the broader AD research community. The Imaging Core has supported a number of federally funded grants as well as Project 1 (Zelinski) and it now plays an important role in supported new Projects 1 (Nation) and 2 (Braskie). INI now provides integration of ALL data between the other cores: Administrative, Clinical, Neuropathology, Data and ORE Cores. Dr. Zlokovic has also led a new direction for the Imaging Core in investigating the role of perfusion MRI and permeability of the blood brain barrier in relation to the pathogenesis of AD. This ties in nicely with the overall vascular mission of the USC ADRC, which is to elucidate vascular contributions to AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005142-35
Application #
9692621
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
2021-03-31
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
35
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Aydogan, Dogu Baran; Jacobs, Russell; Dulawa, Stephanie et al. (2018) When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity. Brain Struct Funct 223:2841-2858
Gahm, Jin Kyu; Shi, Yonggang; Alzheimer’s Disease Neuroimaging Initiative (2018) Riemannian metric optimization on surfaces (RMOS) for intrinsic brain mapping in the Laplace-Beltrami embedding space. Med Image Anal 46:189-201
Emrani, Sheina; Libon, David J; Lamar, Melissa et al. (2018) Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. J Alzheimers Dis 61:917-928
Hernandez, Gerson; Zhao, Liqin; Franke, Adrian A et al. (2018) Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor ?-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause 25:191-196
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Ho, Jean K; Nation, Daniel A; Alzheimer’s Disease Neuroimaging Initiative (2018) Neuropsychological Profiles and Trajectories in Preclinical Alzheimer's Disease. J Int Neuropsychol Soc 24:693-702
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104

Showing the most recent 10 out of 590 publications