The Administrative Core (Core A) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) will be responsible for the overall management of the ADRC, by providing an environment that fosters new avenues of clinical and basic research, trains new investigators, and creates increased productivity in research related to AD. To accomplish this overarching goal it will: (1) coordinate and integrate the ADRC Cores and individual research Projects, as well as studies that are associated with the ADRC that are related to the Center mission;(2) interact with other Alzheimer Centers, the National Alzheimer Coordinating Center (NACC) and other national collaborative activities, in order to maximize progress in AD research throughout the country;(3) oversee the Pilot Project program that provides seed funding for promising research proposals by coordinating: announcements about the program to the scientific community, the review and selection of the projects to be funded (with approval by the NIA), and oversight of the scientific productivity of the funded projects;(4) interact with the lay community to further the goals ofthe ADRC, including the coordination of media outreach by the Center, as well as with the National Institute on Aging;(5) review the utilization of funds and resource allocation that supports the research, training and data management/statistical enterprises ofthe ADRC;and (5) insure compliance with JHU and NIH policies concerning protection of human subjects, animal welfare, ethical conduct of behavior, financial requirements, and the sharing of data, samples and model organisms. In order to maintain the excellence ofthe Center the Administrative Core will coordinate annual reviews by both an External and Internal Advisory Committee.

Public Health Relevance

The Johns Hopkins Alzheimer's Disease Research Center (ADRC) will address many ofthe topics important to dementia research, with a particular focus on the understanding the eariiest phases of Alzheimer's disease (AD). This approach is important if we are ultimately going to be able to diagnose and treat AD as eariy as possible. The ADRC fosters interactions among scientists who are pursuing this overarching theme.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG005146-31
Application #
8662617
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Hohman, Timothy J; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 75:989-998
Kageyama, Yusuke; Saito, Atsushi; Pletnikova, Olga et al. (2018) Amyloid ? toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep 8:16895
Kales, Helen C; Gitlin, Laura N; Stanislawski, Barbara et al. (2018) Effect of the WeCareAdvisor™ on family caregiver outcomes in dementia: a pilot randomized controlled trial. BMC Geriatr 18:113
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Reagh, Zachariah M; Noche, Jessica A; Tustison, Nicholas J et al. (2018) Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits. Neuron 97:1187-1198.e4
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Samus, Quincy M; Black, Betty Smith; Bovenkamp, Diane et al. (2018) Home is where the future is: The BrightFocus Foundation consensus panel on dementia care. Alzheimers Dement 14:104-114
Shi, Liu; Baird, Alison L; Westwood, Sarah et al. (2018) A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication. J Alzheimers Dis 62:1181-1198
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679

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