The Clinical Core (Core B) of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) will be responsible for recruiting and following a diverse group of research subjects to support research projects associated with the ADRC. The Clinical Core accomplishes this overarching goal working closely with ADRC leadership and with the other Cores and Projects. The subjects in the Core include: (1) cognitively normal controls, (2) subjects meeting criteria for Mild Cognitive Impaimient (MCI), (3) patients with Alzheimer's disease (AD), and (4) patients with other related dementias. These cohorts include subjects recruited through the Clinic at Johns Hopkins Medical Institutions (known as the 'Clinic Cohort') as well as the subjects recruited through the Baltimore Longitudinal Study on Aging (BLSA) (known as the 'BLSA Cohort'). These subjects receive annual, standardized medical, neurologic, psychiatric and neuropsychological evaluations. Well-characterized, diverse subjects will be made available to research projects associated with the ADRC, working closely with the Education Core. The Clinical Core will work with the Neuropathology Core to collect, store and analyze plasma, serum, CSF, and DNA from normal controls, individuals with MCI, and cases of AD and related dementias, and to complete APOE genotyping on subjects. Core B will work closely with Core E and Core D to maintain a high autopsy rate (greater than 70%). Investigators in Core B will participate in collaborative research with other AD Centers, including multi-center therapeutic clinical trials related to AD. Core B will work with Core C to provide clinical data to the National Alzheimer's Coordinating Center (NACC) to further interdisciplinary research in AD.
The Johns Hopkins Alzheimer's Disease Research Center (ADRC) will address many of the topics important to dementia research, with a particular focus on the understanding the earliest phases of Alzheimer's disease (AD). This approach is important if we are ultimately going to be able to diagnose and treat AD as early as possible. The ADRC fosters interactions among scientists who are pursuing this overarching theme.
|Geiger, Joshua T; Ding, Jinhui; Crain, Barbara et al. (2016) Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies. Neurobiol Dis 94:55-62|
|Mata, Ignacio F; Leverenz, James B; Weintraub, Daniel et al. (2016) GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Mov Disord 31:95-102|
|Gross, Alden L; Mungas, Dan M; Leoutsakos, Jeannie-Marie S et al. (2016) Alzheimer's disease severity, objectively determined and measured. Alzheimers Dement (Amst) 4:159-168|
|Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717|
|Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25|
|Huo, Yuankai; Plassard, Andrew J; Carass, Aaron et al. (2016) Consistent cortical reconstruction and multi-atlas brain segmentation. Neuroimage 138:197-210|
|Gruenewald, Tara L; Tanner, Elizabeth K; Fried, Linda P et al. (2016) The Baltimore Experience Corps Trial: Enhancing Generativity via Intergenerational Activity Engagement in Later Life. J Gerontol B Psychol Sci Soc Sci 71:661-70|
|Oh, Esther S; Sieber, Frederick E; Leoutsakos, Jeannie-Marie et al. (2016) Sex Differences in Hip Fracture Surgery: Preoperative Risk Factors for Delirium and Postoperative Outcomes. J Am Geriatr Soc 64:1616-21|
|Yesavage, Jerome A; Taylor, Joy L; Friedman, Leah et al. (2016) Principal components analysis of agitation outcomes in Alzheimer's disease. J Psychiatr Res 79:4-7|
|McCutcheon, Sarah T; Han, Dingfen; Troncoso, Juan et al. (2016) Clinicopathological correlates of depression in early Alzheimer's disease in the NACC. Int J Geriatr Psychiatry 31:1301-1311|
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