Abstract

The Washington University ADRC has been functioning since 1985. Emphasis on the work of the Center has focused on interdisciplinary longitudinal clinical analysis of dementia of the Alzheimer's type and the study of clinicopathologic correlates, with emphasis on distinguishing the earliest symptoms of AD. The ADRC performs and provides logistical and material support for research projects and this and many other institutes. It also provides for a range of informational and training activities aimed at both the professional and lay communities. To execute these activities the ADRC consists the ADRC consists of five Cores, Administrative, Clinical, Biostatistics, Neuropathology and Tissue Resource, and Training and Information Transfer (TITC). Two Satellites are supported by the Center. An African American Outreach Satellite of the Clinical Core designed to provide services to the African American Community in St. Louis and to increase the participation. of these subjects in the research activities of the Clinical Core. The Missouri/Iowa Satellite of TITC is designed to provide informational services to the rural populations of the states and the physicians and other health professionals that serve them Four research projects will be carried out using genetic, cell biological, biochemical, and neuroimaging, technologies to address fundamental mechanisms of the pathogenesis of Alzheimer's disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG005681-21S2
Application #
6952541
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Phelps, Creighton H
Project Start
1985-09-30
Project End
2005-04-30
Budget Start
2004-09-30
Budget End
2005-04-30
Support Year
21
Fiscal Year
2004
Total Cost
$2,000
Indirect Cost

  Institution

Name
Washington University
Department
Neurology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Ibanez, Laura; Dube, Umber; Davis, Albert A et al. (2018) Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease. Front Neurosci 12:230
Schindler, Suzanne E; Gray, Julia D; Gordon, Brian A et al. (2018) Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement 14:1460-1469
Roe, Catherine M; Babulal, Ganesh M; Mishra, Shruti et al. (2018) Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease. J Alzheimers Dis 61:509-513
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Broce, Iris; Karch, Celeste M; Wen, Natalie et al. (2018) Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med 15:e1002504
Lucey, Brendan P; Hicks, Terry J; McLeland, Jennifer S et al. (2018) Effect of sleep on overnight cerebrospinal fluid amyloid ? kinetics. Ann Neurol 83:197-204
Armstrong, Richard A; McKee, Ann C; Stein, Thor D et al. (2018) Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci :
Liao, Fan; Li, Aimin; Xiong, Monica et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. J Clin Invest 128:2144-2155

Showing the most recent 10 out of 952 publications