Core - Image Analysis

Unnerstall, James R.

Abstract

The Imaging Core (Core D) is based on an existing image analysis facility at the UHC AC laboratories. Two PC-based image analysis workstations are available for macroscopic and microscopic (Olympus Vannox AHS automated microscope) image analysis. These workstations are fitted with Dage 68 and 81 videocameras, Epyx digitizing boards and appropriate high resolution monitors. Software provides for image acquisition, registration, enhancement, background correction, and filtering programs are available for autoradiography, gels, morphometric analysis of tissue sections, including immunocytochemistry and in situ hybridization. Enhancements, including adding an automated stage are planned as a part of this proposal. The Neuropathology Core (Core E) and two projects (Project #1, Microvessels; and Project #2, Amyloid) as well as pilot grants will be supported by core functions. Particular emphasis of the Imaging Core will be on developing and validating standardized procedures for automating measurements currently done manually (grains, neurons, etc)

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Specialized Center (P50)
• Project #: 5P50AG008012-03
• Application #: 3809394
• Support Year: 3
• Fiscal Year: 1990

Institution

• Name: Case Western Reserve University
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Moon, Heehyul; Townsend, Aloen L; Whitlatch, Carol J et al. (2017) Quality of Life for Dementia Caregiving Dyads: Effects of Incongruent Perceptions of Everyday Care and Values. Gerontologist 57:657-666

Moon, Heehyul; Townsend, Aloen L; Dilworth-Anderson, Peggye et al. (2016) Predictors of Discrepancy Between Care Recipients With Mild-to-Moderate Dementia and Their Caregivers on Perceptions of the Care Recipients' Quality of Life. Am J Alzheimers Dis Other Demen 31:508-15

Nagpal, Neha; Heid, Allison R; Zarit, Steven H et al. (2015) Religiosity and quality of life: a dyadic perspective of individuals with dementia and their caregivers. Aging Ment Health 19:500-6

Merritt, Marcellus M; McCallum, T J (2013) Too much of a good thing?: Positive religious coping predicts worse diurnal salivary cortisol patterns for overwhelmed African American female dementia family caregivers. Am J Geriatr Psychiatry 21:46-56

Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2013) Values and preferences of individuals with dementia: perceptions of family caregivers over time. Gerontologist 53:293-302

Pirisinu, Laura; Nonno, Romolo; Esposito, Elena et al. (2013) Small ruminant nor98 prions share biochemical features with human gerstmann-sträussler-scheinker disease and variably protease-sensitive prionopathy. PLoS One 8:e66405

Xiao, Xiangzhu; Yuan, Jue; Haïk, Stéphane et al. (2013) Glycoform-selective prion formation in sporadic and familial forms of prion disease. PLoS One 8:e58786

Zarit, Steven H; Lee, Jeong E; Barrineau, Mary J et al. (2013) Fidelity and acceptability of an adaptive intervention for caregivers: an exploratory study. Aging Ment Health 17:197-206

Binoy Mathew, K V; Eapen, Charu; Kumar, P Senthil (2012) Reliability and Concurrent Validity of Dynamic Rotator Stability Test-A Cross Sectional study. Indian J Physiother Occup Ther 6:76-81

Reamy, Allison M; Kim, Kyungmin; Zarit, Steven H et al. (2011) Understanding discrepancy in perceptions of values: individuals with mild to moderate dementia and their family caregivers. Gerontologist 51:473-83