Abstract

The proposed Alzheimer Disease Research Center will build upon the present clinical science and basic strengths in studying Alzheimer's disease coordinated through the Department of Neurology at the Baylor College of Medicine. This ADRC will permit significant expansion in both the scope and size of our ongoing multidisciplinary efforts in helping patients and families with this disease and in studying this disease at the molecular, cellular, genetic, and clinical levels. The research component includes both clinical and basic science studies. The basic science studies investigate molecular mechanisms of neural survival, differentiation., and the synaptic mechanism of long-term potentiation. Other basic science investigations will examine the biochemical mechanism of amyloid production and of tau protein. Pilot studies will be initiated on the genetic abnormalities in inherited Alzheimer's disease. Two clinical studies will examine the abnormalities in central auditory processing and in language in Alzheimer's disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG008664-04
Application #
3104889
Study Section
Aging Review Committee (AGE)
Project Start
1989-09-29
Project End
1994-05-31
Budget Start
1992-07-15
Budget End
1993-05-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Doody, R; Pavlik, V; Massman, Paul et al. (2005) Changing patient characteristics and survival experience in an Alzheimer's center patient cohort. Dement Geriatr Cogn Disord 20:198-208
Waring, Stephen C; Doody, Rachelle S; Pavlik, Valory N et al. (2005) Survival among patients with dementia from a large multi-ethnic population. Alzheimer Dis Assoc Disord 19:178-83
Hoyt, Brian D; Massman, Paul J; Schatschneider, Christopher et al. (2005) Individual growth curve analysis of APOE epsilon 4-associated cognitive decline in Alzheimer disease. Arch Neurol 62:454-9
Snow, A Lynn; Norris, Margaret P; Doody, Rachelle et al. (2004) Dementia Deficits Scale. Rating self-awareness of deficits. Alzheimer Dis Assoc Disord 18:22-31
Doody, Rachelle Smith; Dunn, J Kay; Huang, Eugene et al. (2004) A method for estimating duration of illness in Alzheimer's disease. Dement Geriatr Cogn Disord 17:1-4
Atchison, Timothy B; Bradshaw, Major; Massman, Paul J (2004) Investigation of profile difference between Alzheimer's disease patients declining at different rates: examination of baseline neuropsychological data. Arch Clin Neuropsychol 19:1007-15
Graham, David P; Cully, Jeffrey A; Snow, A Lynn et al. (2004) The Alzheimer's Disease Assessment Scale-Cognitive subscale: normative data for older adult controls. Alzheimer Dis Assoc Disord 18:236-40
Clark, Christopher M; Xie, Sharon; Chittams, Jesse et al. (2003) Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch Neurol 60:1696-702
Davis, Robert N; Massman, Paul J; Doody, Rachelle S (2003) WAIS-R factor structure in Alzheimer's disease patients: a comparison of alternative models and an assessment of their generalizability. Psychol Aging 18:836-43
Davis, Robert N; Massman, Paul J; Doody, Rachelle S (2003) Effects of blood pressure on neuropsychological functioning in Alzheimer's disease. Arch Clin Neuropsychol 18:19-32

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