Research investigating new medications and diagnostics for Alzheimer's disease (AD) is critical and will require large numbers of patients and normal control individuals. This """"""""therapeutic imperative"""""""" is the theme of the Alzheimer Disease Research Center (ADRC) at UCLA. Recruitment of participants, retention of subjects for the duration of research projects, and the assurance of research populations that are representative of the larger disease population are the objectives of the Recruitment and Education Core (REC) at the UCLA ADRC. The REC has been infused with substantial resources to make accomplishment of these objectives realistic. The REC will engage in a wide number of unique and innovative recruitment, retention, community outreach, and educational strategies. The REC sponsors a variety of educational conferences, many of which are done in partnership with community organizations such as the Alzheimer's Association. A clear need in AD research is to increase representation of minorities. In the last grant cycle, REC reached 20,000 educational event attendees, including 1000 clinicians and over 900 minority community members. REC has a robust array of minority-oriented activities for the new grant cycle. New to this proposal, the REC will develop of African American and Hispanic Community Advisory Boards to guide minority recruitment efforts. The REC will also partner with Healthcare Communications Group to increase public awareness of AD research, and with the PriMed Institute to educate primary care physicians on AD management guidelines and the need for increased referrals to research. The REC will continue to work closely with the other Cores of the ADRC. This includes collaborations with the Data Management and Statistics Core to better estimate the number of needed research subjects;with the Clinical Core to ensure the proper collection of data for the Uniform Data Set (UDS);with the Neuropathology Core to conduct the successful ClinicoPathologic Conference (CPC);and with Administrative Core to ensure the maximal functionality of the Center website and other tools to keep subjects, donors, and the general community aware of the Center's activities. All REC activities will be continually evaluated for success. This includes a constant monitoring of the sources of enrolled research subjects. Evaluations will dictate future programs and resource use.

Public Health Relevance

The recruitment and retention of patients to participate in AD research is critical to the success of the therapeutic imperative. Subject enrollment must be representative of the larger AD population. Many barriers exist to the enrollment of a representative research population and the activities of the REC are aimed at overcoming these barriers and supporting the other Cores in the UCLA ADRC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016570-14
Application #
8450825
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
14
Fiscal Year
2013
Total Cost
$102,314
Indirect Cost
$21,112
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Joe, Elizabeth; Medina, Luis D; Ringman, John M et al. (2018) 1H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease. Brain Imaging Behav :
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360

Showing the most recent 10 out of 727 publications