Research investigating new medications and diagnostics for Alzheimer's disease (AD) is critical and will require large numbers of patients and normal control individuals. This """"""""therapeutic imperative"""""""" is the theme of the Alzheimer Disease Research Center (ADRC) at UCLA. Recruitment of participants, retention of subjects for the duration of research projects, and the assurance of research populations that are representative of the larger disease population are the objectives of the Recruitment and Education Core (REC) at the UCLA ADRC. The REC has been infused with substantial resources to make accomplishment of these objectives realistic. The REC will engage in a wide number of unique and innovative recruitment, retention, community outreach, and educational strategies. The REC sponsors a variety of educational conferences, many of which are done in partnership with community organizations such as the Alzheimer's Association. A clear need in AD research is to increase representation of minorities. In the last grant cycle, REC reached 20,000 educational event attendees, including 1000 clinicians and over 900 minority community members. REC has a robust array of minority-oriented activities for the new grant cycle. New to this proposal, the REC will develop of African American and Hispanic Community Advisory Boards to guide minority recruitment efforts. The REC will also partner with Healthcare Communications Group to increase public awareness of AD research, and with the PriMed Institute to educate primary care physicians on AD management guidelines and the need for increased referrals to research. The REC will continue to work closely with the other Cores of the ADRC. This includes collaborations with the Data Management and Statistics Core to better estimate the number of needed research subjects;with the Clinical Core to ensure the proper collection of data for the Uniform Data Set (UDS);with the Neuropathology Core to conduct the successful ClinicoPathologic Conference (CPC);and with Administrative Core to ensure the maximal functionality of the Center website and other tools to keep subjects, donors, and the general community aware of the Center's activities. All REC activities will be continually evaluated for success. This includes a constant monitoring of the sources of enrolled research subjects. Evaluations will dictate future programs and resource use.

Public Health Relevance

The recruitment and retention of patients to participate in AD research is critical to the success of the therapeutic imperative. Subject enrollment must be representative of the larger AD population. Many barriers exist to the enrollment of a representative research population and the activities of the REC are aimed at overcoming these barriers and supporting the other Cores in the UCLA ADRC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016570-15
Application #
8662640
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Jutkowitz, Eric; MacLehose, Richard F; Gaugler, Joseph E et al. (2017) Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients. J Gerontol A Biol Sci Med Sci 72:251-258
Sokolow, Sophie; Li, Xiaohui; Chen, Lucia et al. (2017) Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment. J Alzheimers Dis 56:229-237
Ringman, John M; Casado, Maria; Van Berlo, Victoria et al. (2017) A novel PSEN1 (S230N) mutation causing early-onset Alzheimer's Disease associated with prosopagnosia, hoarding, and Parkinsonism. Neurosci Lett 657:11-15
Jefferson-George, Kyra S; Wolk, David A; Lee, Edward B et al. (2017) Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimers Dement 13:1048-1053
Katsumata, Yuriko; Nelson, Peter T; Ellingson, Sally R et al. (2017) Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. Neurobiol Aging 53:193.e17-193.e25
Ringman, John M (2017) Update on Alzheimer's and the Dementias: Introduction. Neurol Clin 35:171-174
Qian, Jing; Hyman, Bradley T; Betensky, Rebecca A (2017) Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. JAMA Neurol 74:540-548
Chang, Timothy S; Teng, Edmond; Elashoff, David et al. (2017) Optimizing Effect Sizes With Imaging Enrichment and Outcome Choices for Mild Alzheimer Disease Clinical Trials. Alzheimer Dis Assoc Disord 31:19-26
Blanken, Anna E; Hurtz, Sona; Zarow, Chris et al. (2017) Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI. Neuroimage Clin 15:56-61
Kim, Julia; Schweizer, Tom A; Fischer, Corinne E et al. (2017) The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer's Disease. J Alzheimers Dis 55:381-389

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