CORE A: ADMINISTRATIVE CORE The goal of the Administrative Core is to set the overall direction of the center, ensure the optimal utilization of resources and provide a sense of "Centerness". The Core will provide the infrastructure and environment to enhance excellence in basic science research, clinical and translational research.
Our specific aims are outlined in the RFA and include coordinating and integrating activities among the Cores and projects, promoting interactions with the scientific and lay communities to develop relevant goals for the Center and coordinating and organizing internal and external advisory committee meetings. The Core will solicit, oversee the review and submission of Pilot Projects to the NIA, and monitor Pilot Project progress. The Core will also provide fiscal accountability and business management expertise to the Center and assure compliance with human subject protection, animal welfare, scientific integrity and data and sample sharing The Core will interact with other Centers and the National Alzheimer's Coordinating Center and develop trans-ADC and outside research projects. The Core will build upon the rich opportunities within UCI to enhance ADRC research including providing Core resources for the development of research on brain aging and AD to UCI investigators. Finally the Core will coordinate with NIA on media coverage and interact with the surrounding lay and professional communities to communicate the latest research from the Center and field. Overall, the Administrative Core seeks to create a vibrant, innovative research and training environment to understand the basis for the decline of cognitive function with age, the mechanisms that cause the onset of AD and discover treatment to prevent and treat AD.
|Mitchell, Joel C; Dick, Malcolm B; Wood, Amanda E et al. (2015) The utility of the Dementia Severity Rating Scale in differentiating mild cognitive impairment and Alzheimer disease from controls. Alzheimer Dis Assoc Disord 29:222-8|
|Robinson, John L; Molina-Porcel, Laura; Corrada, Maria M et al. (2014) Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain 137:2578-87|
|Blurton-Jones, Mathew; Spencer, Brian; Michael, Sara et al. (2014) Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther 5:46|
|Berchtold, Nicole C; Sabbagh, Marwan N; Beach, Thomas G et al. (2014) Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease. Neurobiol Aging 35:1961-72|
|Iulita, M Florencia; Do Carmo, Sonia; Ower, Alison K et al. (2014) Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain 137:860-72|
|Holler, Christopher J; Davis, Paulina R; Beckett, Tina L et al. (2014) Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis 42:1221-7|
|Pensalfini, Anna; Albay 3rd, Ricardo; Rasool, Suhail et al. (2014) Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiol Dis 71:53-61|
|Sosa, Lucas J; Postma, Nienke L; Estrada-Bernal, Adriana et al. (2014) Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome. FASEB J 28:195-205|
|Perluigi, Marzia; Pupo, Gilda; Tramutola, Antonella et al. (2014) Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta 1842:1144-53|
|Di Domenico, Fabio; Pupo, Gilda; Tramutola, Antonella et al. (2014) Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med 71:270-80|
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