CORE A: ADMINISTRATIVE CORE The goal of the Administrative Core is to set the overall direction of the center, ensure the optimal utilization of resources and provide a sense of """"""""Centerness"""""""". The Core will provide the infrastructure and environment to enhance excellence in basic science research, clinical and translational research.
Our specific aims are outlined in the RFA and include coordinating and integrating activities among the Cores and projects, promoting interactions with the scientific and lay communities to develop relevant goals for the Center and coordinating and organizing internal and external advisory committee meetings. The Core will solicit, oversee the review and submission of Pilot Projects to the NIA, and monitor Pilot Project progress. The Core will also provide fiscal accountability and business management expertise to the Center and assure compliance with human subject protection, animal welfare, scientific integrity and data and sample sharing The Core will interact with other Centers and the National Alzheimer's Coordinating Center and develop trans-ADC and outside research projects. The Core will build upon the rich opportunities within UCI to enhance ADRC research including providing Core resources for the development of research on brain aging and AD to UCI investigators. Finally the Core will coordinate with NIA on media coverage and interact with the surrounding lay and professional communities to communicate the latest research from the Center and field. Overall, the Administrative Core seeks to create a vibrant, innovative research and training environment to understand the basis for the decline of cognitive function with age, the mechanisms that cause the onset of AD and discover treatment to prevent and treat AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG016573-14
Application #
8450794
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
14
Fiscal Year
2013
Total Cost
$187,338
Indirect Cost
$64,724
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Torres, Maria D; Garcia, Octavio; Tang, Cindy et al. (2018) Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radic Biol Med 114:10-14
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Largent, Emily A; Karlawish, Jason; Grill, Joshua D (2018) Study partners: essential collaborators in discovering treatments for Alzheimer's disease. Alzheimers Res Ther 10:101
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Miranda, Andre M; Herman, Mathieu; Cheng, Rong et al. (2018) Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Rep 23:2967-2975
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Melikyan, Zarui A; Greenia, Dana E; Corrada, Maria M et al. (2018) Recruiting the Oldest-old for Clinical Research. Alzheimer Dis Assoc Disord :
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600

Showing the most recent 10 out of 518 publications