CORE C: DATA MANAGEMENT and STATISTICS CORE The overarching goal of the Data Management and Statistics Core (DMSC) within the University of California-Irvine (UCI) Alzheimer's Disease Research Center (ADRC) is to provide logistical and intellectual support to all ADRC investigators at all phases of scientific projects. As such, the mission of the DMSC faculty and staff is to be intimately involved in the conception, design, implementation, analysis, and reporting of research conducted by members of the ADRC. Strong statistical design, clean and organized data, and efficient data analyses are crucial components to achieving the scientific goals set forth by the UCI ADRC. With this in mind the DMSC emphasizes regular communication with ADRC investigators and proactive involvement in ADRC-sponsored projects. While a large portion of effort from DMSC faculty has been devoted to providing collaboration and service to ADRC investigators, the DMSC will also emphasize and encourage the development of independent research programs among members of the DMSC. These research projects will include the development and validation of novel data collection mechanisms, the development of new statistical methodology for addressing missing data, and the development of statistical methods for survival analysis. These DMSC-specific research endeavors will not only increase the intellectual contribution of the DMSC to the scientific community at large, but will most certainly lead to improved methods for collecting, entering, and analyzing complex data obtained through local ADRC projects.
The DMSC plays a critical role in the successful research conducted by the UCI ADRC and is instrumental in providing valuable clinical and pathological data to the National Alzheimer's Coordinating Center. The DMSC provides comprehensive data management support to all ADRC Cores and projects. In addition, the DMSC provides statistical support to all ADRC investigators including project PIs.
|Katsumata, Yuriko; Nelson, Peter T; Ellingson, Sally R et al. (2017) Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. Neurobiol Aging 53:193.e17-193.e25|
|Brenowitz, Willa D; Keene, C Dirk; Hawes, Stephen E et al. (2017) Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. Neurobiol Aging 53:83-92|
|Shelton, Lindsey B; Baker, Jeremy D; Zheng, Dali et al. (2017) Hsp90 activator Aha1 drives production of pathological tau aggregates. Proc Natl Acad Sci U S A 114:9707-9712|
|Moga, Daniela C; Abner, Erin L; Wu, Qishan et al. (2017) Bladder antimuscarinics and cognitive decline in elderly patients. Alzheimers Dement (N Y) 3:139-148|
|Stark, Shauna M; Reagh, Zachariah M; Yassa, Michael A et al. (2017) What's in a context? Cautions, limitations, and potential paths forward. Neurosci Lett :|
|Sennik, Simrin; Schweizer, Tom A; Fischer, Corinne E et al. (2017) Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data. J Alzheimers Dis 55:1519-1528|
|Chang, Timothy S; Teng, Edmond; Elashoff, David et al. (2017) Optimizing Effect Sizes With Imaging Enrichment and Outcome Choices for Mild Alzheimer Disease Clinical Trials. Alzheimer Dis Assoc Disord 31:19-26|
|Abud, Edsel M; Ramirez, Ricardo N; Martinez, Eric S et al. (2017) iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron 94:278-293.e9|
|Kim, Julia; Schweizer, Tom A; Fischer, Corinne E et al. (2017) The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer's Disease. J Alzheimers Dis 55:381-389|
|Neu, Scott C; Pa, Judy; Kukull, Walter et al. (2017) Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis. JAMA Neurol 74:1178-1189|
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