CORE C: DATA MANAGEMENT and STATISTICS CORE The overarching goal of the Data Management and Statistics Core (DMSC) within the University of California-Irvine (UCI) Alzheimer's Disease Research Center (ADRC) is to provide logistical and intellectual support to all ADRC investigators at all phases of scientific projects. As such, the mission of the DMSC faculty and staff is to be intimately involved in the conception, design, implementation, analysis, and reporting of research conducted by members of the ADRC. Strong statistical design, clean and organized data, and efficient data analyses are crucial components to achieving the scientific goals set forth by the UCI ADRC. With this in mind the DMSC emphasizes regular communication with ADRC investigators and proactive involvement in ADRC-sponsored projects. While a large portion of effort from DMSC faculty has been devoted to providing collaboration and service to ADRC investigators, the DMSC will also emphasize and encourage the development of independent research programs among members of the DMSC. These research projects will include the development and validation of novel data collection mechanisms, the development of new statistical methodology for addressing missing data, and the development of statistical methods for survival analysis. These DMSC-specific research endeavors will not only increase the intellectual contribution of the DMSC to the scientific community at large, but will most certainly lead to improved methods for collecting, entering, and analyzing complex data obtained through local ADRC projects.

Public Health Relevance

The DMSC plays a critical role in the successful research conducted by the UCI ADRC and is instrumental in providing valuable clinical and pathological data to the National Alzheimer's Coordinating Center. The DMSC provides comprehensive data management support to all ADRC Cores and projects. In addition, the DMSC provides statistical support to all ADRC investigators including project PIs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
3P50AG016573-14S1
Application #
8668860
Study Section
National Institute on Aging Initial Review Group (NIA)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
14
Fiscal Year
2013
Total Cost
$46,388
Indirect Cost
$15,967
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Cox, Chelsea G; Ryan B A, Mary M; Gillen, Daniel L et al. (2018) A Preliminary Study of Clinical Trial Enrollment Decisions Among People With Mild Cognitive Impairment and Their Study Partners. Am J Geriatr Psychiatry :
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Agrawal, Sudhanshu; Abud, Edsel M; Snigdha, Shikha et al. (2018) IgM response against amyloid-beta in aging: a potential peripheral protective mechanism. Alzheimers Res Ther 10:81
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307

Showing the most recent 10 out of 518 publications