The First National Plan to Address Alzheimer's Disease was released in May of 2012 and set a blueprint for research in Alzheimer's disease (AD) to achieve the goal of effective treatment and prevention of the disease by 2025. Toward that goal, the Mayo Alzheimer's Disease Research Center (ADRC) is pursuing research to accomplish that goal. The Center will be comprised of five cores: Administrative Core to oversee the operations of the Center;Clinical Core to recruit and characterize subjects along the AD spectrum and for the AD-related dementias;Data Management and Statistical Core to collect, refine and analyze data and be compliant with the requirements of the National Alzheimer's Coordinating Center;Neuropathology Core to perform detailed neuropathological studies on autopsy specimens and disseminate genetic and other biospecimens to collaborators;Outreach, Recruitment and Education Core to assist in the recruitment and characterization of subjects for research purposes. The ADRC is also proposing three new research projects including one by a junior investigator. Project 1, """"""""Improving Clinical Prediction of Dementia Pathology and Long-Term Outcomes Using Imaging,"""""""" by Prashanthi Vemuri, Ph.D., will develop a software methodology using clinical and imaging data to predict dementia subtypes;Project 2, """"""""Validating HDAC6 as a Novel Therapeutic Target for Alzheimer's Tauopathy,"""""""" principal investigator Leonard Petrucelli, Ph.D., will validate inhibition of cytosolic histone deacetylase 6 that modulates the accumulation of hyperphosphorylated tau as a possible strategy for the treatment of AD;Project 3, """"""""ApoE Isoforms in Brain Vasculature and CAA,"""""""" Goujun Bu, Ph.D., will investigate the roles of ApoE and ApoE receptors in the pathogenesis of AD. The ADRC will continue to maintain an active cohort of research subjects and will recruit a new cohort of at-risk subjects for Lewy body disorders. The Center will continue to serve as the nidus for AD research at the Mayo Clinic and will interact with the National Institute on Aging and other Alzheimer's Disease Centers around the country. The Center will remain flexible and adapt to new directions as the field of AD and related dementia research progresses.

Public Health Relevance

Alzheimer's disease (AD) may be the defining healthcare condition of our generation. The First Plan to Address Alzheimer's Disease for the United States was released in May of 2012 and outlined a blueprint for research and care on individuals with AD and AD-related dementias. The Mayo Alzheimer's Disease Research Center will pursue themes related to the National Plan in an attempt to have an impact on this disease within ten years.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Phelps, Creighton H
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Raman, Mekala R; Shu, Yunhong; Lesnick, Timothy G et al. (2017) Regional T1 relaxation time constants in Ex vivo human brain: Longitudinal effects of formalin exposure. Magn Reson Med 77:774-778
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
McCarter, Stuart J; St Louis, Erik K; Sandness, David J et al. (2017) Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. Sleep Med 33:23-29
Rogers, Justin T; Liu, Chia-Chen; Zhao, Na et al. (2017) Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice. Neurobiol Aging 53:112-121
Sanchez-Contreras, Monica; Heckman, Michael G; Tacik, Pawel et al. (2017) Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration. Mov Disord 32:115-123
Pichler, Michael; Vemuri, Prashanthi; Rabinstein, Alejandro A et al. (2017) Prevalence and Natural History of Superficial Siderosis: A Population-Based Study. Stroke 48:3210-3214
Vemuri, Prashanthi; Lowe, Val J; Knopman, David S et al. (2017) Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition. Alzheimers Dement (Amst) 6:21-30
Whitwell, Jennifer L; Lowe, Val J; Tosakulwong, Nirubol et al. (2017) [18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy. Mov Disord 32:124-133
Raman, Mekala R; Tosakulwong, Nirubol; Zuk, Samantha M et al. (2017) Influence of preeclampsia and late-life hypertension on MRI measures of cortical atrophy. J Hypertens 35:2479-2485
Tripodis, Yorghos; Alosco, Michael L; Zirogiannis, Nikolaos et al. (2017) The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer's Disease Dementia. J Alzheimers Dis 59:251-263

Showing the most recent 10 out of 900 publications