The objectives of the Data Management and Statistics (DMS) Core is to provide the data management and statistical expertise that is vital to the orderiy progress and success ofthe research projects and ancillary studies of the Emory University Alzheimer's Disease Research Center (ADRC). The DSM Core will be responsible for the following activities related to the ADRC:
Aim 1. To provide, manage and maintain a high-quality research database that supports the research projects, cores, and ancillary studies of the Emory University ADRC;to cooperate with the Clinical Core in the human subjects protection administration for research subjects;to implement technological and practical policies and procedures to preserve the confidentiality of all patient and control subject records;oversee and manage the collection of data for research projects conducted by Emory investigators working with the ADRC.
Aim 2. To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation of ADRC research studies.
Aim 3. To cooperate with and share Uniform Data Set (UDS) data with the National Alzheimer's Coordinating Center (NACC). We have developed a data entry system and a manual of standard operating procedures for this system which allows secure and valid data entry for both UDS data and data on all neurology patients. We plan to move to Web-based data entry in collaboration with other ADRCs, via adoption of a system developed by the UCSF ADRC. We have in place a system to provide research subjects and data to ADRC investigators in a manner that protects patients'confidentiality and complies with Emory IRB guidelines. We coordinate closely with other cores, in particular the Clinical and Neuropathology cores. We provide statistical and epidemiologic support to ADRC projects and investigators via two statisticians and one epidemiologist who are part of the core. Furthermore, core personnel conduct their own research, which has led to past publications and which will continue in the new grant period.

Public Health Relevance

The Data Management and Statistics Core is an essential component ofthe ADRC, enabling us to comply with NACC's requirement for UDS subjects, to rapidly transmit needed data to ADRC investigators in a secure fashion protecting patient confidentiality, to provide statistical help to ADRC investigators, and to develop new statistical techniques which will be of use to the field in general.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG025688-08
Application #
8441095
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
8
Fiscal Year
2012
Total Cost
$138,628
Indirect Cost
$49,191
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-9
Zhang, Yuhai; Zhou, Xiao-Hua; Meranus, Dana H et al. (2016) Benzodiazepine Use and Cognitive Decline in Elderly With Normal Cognition. Alzheimer Dis Assoc Disord 30:113-7
LeVine 3rd, Harry; Walker, Lary C (2016) What amyloid ligands can tell us about molecular polymorphism and disease. Neurobiol Aging 42:205-12
Holler, Christopher J; Taylor, Georgia; McEachin, Zachary T et al. (2016) Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener 11:46
Buijsen, R A M; Visser, J A; Kramer, P et al. (2016) Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated primary ovarian insufficiency. Hum Reprod 31:158-68
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
White, Matthew T; Shaw, Leslie M; Xie, Sharon X et al. (2016) Evaluation of Cerebrospinal Fluid Assay Variability in Alzheimer's Disease. J Alzheimers Dis 51:463-70
Rui, Yanfang; Zheng, James Q (2016) Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner. Mol Brain 9:79
Hampstead, B M; Khoshnoodi, M; Yan, W et al. (2016) Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults. Neuroimage 124:997-1008
Seyfried, Nicholas T; Dammer, Eric B; Swarup, Vivek et al. (2016) A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. Cell Syst :

Showing the most recent 10 out of 293 publications