The objectives of the Data Management and Statistics (DMS) Core is to provide the data management and statistical expertise that is vital to the orderiy progress and success ofthe research projects and ancillary studies of the Emory University Alzheimer's Disease Research Center (ADRC). The DSM Core will be responsible for the following activities related to the ADRC:
Aim 1. To provide, manage and maintain a high-quality research database that supports the research projects, cores, and ancillary studies of the Emory University ADRC;to cooperate with the Clinical Core in the human subjects protection administration for research subjects;to implement technological and practical policies and procedures to preserve the confidentiality of all patient and control subject records;oversee and manage the collection of data for research projects conducted by Emory investigators working with the ADRC.
Aim 2. To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation of ADRC research studies.
Aim 3. To cooperate with and share Uniform Data Set (UDS) data with the National Alzheimer's Coordinating Center (NACC). We have developed a data entry system and a manual of standard operating procedures for this system which allows secure and valid data entry for both UDS data and data on all neurology patients. We plan to move to Web-based data entry in collaboration with other ADRCs, via adoption of a system developed by the UCSF ADRC. We have in place a system to provide research subjects and data to ADRC investigators in a manner that protects patients'confidentiality and complies with Emory IRB guidelines. We coordinate closely with other cores, in particular the Clinical and Neuropathology cores. We provide statistical and epidemiologic support to ADRC projects and investigators via two statisticians and one epidemiologist who are part of the core. Furthermore, core personnel conduct their own research, which has led to past publications and which will continue in the new grant period.

Public Health Relevance

The Data Management and Statistics Core is an essential component ofthe ADRC, enabling us to comply with NACC's requirement for UDS subjects, to rapidly transmit needed data to ADRC investigators in a secure fashion protecting patient confidentiality, to provide statistical help to ADRC investigators, and to develop new statistical techniques which will be of use to the field in general.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
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Special Emphasis Panel (ZAG1-ZIJ-4)
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Emory University
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Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204
Devanand, Davangere P; Liu, Xinhua; Brown, Patrick J (2017) Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia. Alzheimer Dis Assoc Disord 31:55-61
Diner, Ian; Dooyema, Jeromy; Gearing, Marla et al. (2017) Generation of Clickable Pittsburgh Compound B for the Detection and Capture of ?-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem 28:2627-2637
LoBue, Christian; Wadsworth, Hannah; Wilmoth, Kristin et al. (2017) Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease. Clin Neuropsychol 31:85-98
Tripodis, Yorghos; Alosco, Michael L; Zirogiannis, Nikolaos et al. (2017) The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer's Disease Dementia. J Alzheimers Dis 59:251-263
Bell, S P; Liu, D; Samuels, L R et al. (2017) Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ?4 and the Risk of Cognitive Decline and Incident Dementia. J Nutr Health Aging 21:1259-1267
Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2017) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement 13:654-662
Wingo, A P; Almli, L M; Stevens, J S et al. (2017) Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs. Mol Psychiatry 22:774-783
Jutkowitz, Eric; Kane, Robert L; Gaugler, Joseph E et al. (2017) Societal and Family Lifetime Cost of Dementia: Implications for Policy. J Am Geriatr Soc 65:2169-2175
Moheb, Negar; Mendez, Mario F; Kremen, Sarah A et al. (2017) Executive Dysfunction and Behavioral Symptoms Are Associated with Deficits in Instrumental Activities of Daily Living in Frontotemporal Dementia. Dement Geriatr Cogn Disord 43:89-99

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