With the maturation of our understanding of disease mechanisms in Alzheimer's disease (AD) and other neurodegenerative disorders, there is an urgent need to relate basic neurobiological advances to patientbased research. To capitalize on scientific advances during the past two decades, the community of basic, translational, and clinical investigators must coordinate our efforts to maximize opportunities to accelerate improvements in clinical care. The Emory ADRC maintains an intense focus on integrative research efforts, and the Clinical Core serves the vital functions of providing clinical infrastructure and facilitating access to research participants to support research on AD and related neurodegenerative disorders. Key themes for the Clinical Core in this competing renewal are to continue to support and strengthen our center's focus on integrative science and expand the participation of African-American elders in these activities. During our initial funding period, the Emory ADRC Clinical Core has worked closely with other elements of our center to establish a strong foundation and demonstrable effectiveness in supporting productive basic and clinical research studies.
The Specific Aims forthe current proposal are 1) to recruit participants for ADRC Research Projects and support translational neurodegenerative disease research at Emory, 2) to maintain a cohort of research participants and contribute top-quality clinical data and biological samples to national coordinating centers, and 3) to maximize participation of African-American elders in ADRCsponsored research and related projects. Through these Aims, we will continue building our capacity to support cutting edge research with a specific emphasis on developing methods to identify and recruit individuals at early stages of cognitive decline to participate in basic research and clinical research on early detection and disease-modifying therapies. We will also continue to explore unique opportunities to ameliorate the existing racial disparities in biomedical research through a unique partnership between the Emory ADRC and leaders in the Atlanta African American community. The themes and goals that are proposed for the Clinical Core are consistent with the overall focus of the Emory ADRC, and it will serve as a powerful proponent for basic and clinical research efforts to advance our abilities to diagnose and treat patients suffering from AD and other neurodegenerative dementing diseases.

Public Health Relevance

The increasing numbers of individuals and their families affected by Alzheimer's disease and related neurodegenerative disorders poses a major public health problem. The proposed work will provide essential support for efforts to understand the causes and accelerate improvements in care of individuals with Alzheimer's disease.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
United States
Zip Code
Zhang, Yuhai; Zhou, Xiao-Hua; Meranus, Dana H et al. (2016) Benzodiazepine Use and Cognitive Decline in Elderly With Normal Cognition. Alzheimer Dis Assoc Disord 30:113-7
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-9
Holler, Christopher J; Taylor, Georgia; McEachin, Zachary T et al. (2016) Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener 11:46
LeVine 3rd, Harry; Walker, Lary C (2016) What amyloid ligands can tell us about molecular polymorphism and disease. Neurobiol Aging 42:205-12
Forrester, Sarah N; Gallo, Joseph J; Smith, Gwenn S et al. (2016) Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia. Am J Geriatr Psychiatry 24:117-25
Buijsen, R A M; Visser, J A; Kramer, P et al. (2016) Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated primary ovarian insufficiency. Hum Reprod 31:158-68
Rui, Yanfang; Zheng, James Q (2016) Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner. Mol Brain 9:79
White, Matthew T; Shaw, Leslie M; Xie, Sharon X et al. (2016) Evaluation of Cerebrospinal Fluid Assay Variability in Alzheimer's Disease. J Alzheimers Dis 51:463-70
Seyfried, Nicholas T; Dammer, Eric B; Swarup, Vivek et al. (2016) A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. Cell Syst :
Hampstead, B M; Khoshnoodi, M; Yan, W et al. (2016) Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults. Neuroimage 124:997-1008

Showing the most recent 10 out of 293 publications