With the maturation of our understanding of disease mechanisms in Alzheimer's disease (AD) and other neurodegenerative disorders, there is an urgent need to relate basic neurobiological advances to patientbased research. To capitalize on scientific advances during the past two decades, the community of basic, translational, and clinical investigators must coordinate our efforts to maximize opportunities to accelerate improvements in clinical care. The Emory ADRC maintains an intense focus on integrative research efforts, and the Clinical Core serves the vital functions of providing clinical infrastructure and facilitating access to research participants to support research on AD and related neurodegenerative disorders. Key themes for the Clinical Core in this competing renewal are to continue to support and strengthen our center's focus on integrative science and expand the participation of African-American elders in these activities. During our initial funding period, the Emory ADRC Clinical Core has worked closely with other elements of our center to establish a strong foundation and demonstrable effectiveness in supporting productive basic and clinical research studies.
The Specific Aims forthe current proposal are 1) to recruit participants for ADRC Research Projects and support translational neurodegenerative disease research at Emory, 2) to maintain a cohort of research participants and contribute top-quality clinical data and biological samples to national coordinating centers, and 3) to maximize participation of African-American elders in ADRCsponsored research and related projects. Through these Aims, we will continue building our capacity to support cutting edge research with a specific emphasis on developing methods to identify and recruit individuals at early stages of cognitive decline to participate in basic research and clinical research on early detection and disease-modifying therapies. We will also continue to explore unique opportunities to ameliorate the existing racial disparities in biomedical research through a unique partnership between the Emory ADRC and leaders in the Atlanta African American community. The themes and goals that are proposed for the Clinical Core are consistent with the overall focus of the Emory ADRC, and it will serve as a powerful proponent for basic and clinical research efforts to advance our abilities to diagnose and treat patients suffering from AD and other neurodegenerative dementing diseases.
The increasing numbers of individuals and their families affected by Alzheimer's disease and related neurodegenerative disorders poses a major public health problem. The proposed work will provide essential support for efforts to understand the causes and accelerate improvements in care of individuals with Alzheimer's disease.
|Matveev, Sergey V; Spielmann, Hans Peter; Metts, Brittney M et al. (2014) A distinct subfraction of A? is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain. J Neurochem 131:356-68|
|England, Heather B; Gillis, M Meredith; Hampstead, Benjamin M (2014) RBANS memory indices are related to medial temporal lobe volumetrics in healthy older adults and those with mild cognitive impairment. Arch Clin Neuropsychol 29:322-8|
|Chopra, Pankaj; Papale, Ligia A; White, Andrew T J et al. (2014) Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice. BMC Genomics 15:131|
|Lohr, Kelly M; Bernstein, Alison I; Stout, Kristen A et al. (2014) Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. Proc Natl Acad Sci U S A 111:9977-82|
|Goldstein, Felicia C; Ashley, Angela V; Miller, Eric et al. (2014) Validity of the montreal cognitive assessment as a screen for mild cognitive impairment and dementia in African Americans. J Geriatr Psychiatry Neurol 27:199-203|
|Kummer, Markus P; Hammerschmidt, Thea; Martinez, Ana et al. (2014) Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J Neurosci 34:8845-54|
|Göttle, Martin; Prudente, Cecilia N; Fu, Rong et al. (2014) Loss of dopamine phenotype among midbrain neurons in Lesch-Nyhan disease. Ann Neurol 76:95-107|
|Richardson, Jason R; Roy, Ananya; Shalat, Stuart L et al. (2014) Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol 71:284-90|
|Feldman, Eva L; Boulis, Nicholas M; Hur, Junguk et al. (2014) Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes. Ann Neurol 75:363-73|
|Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606|
Showing the most recent 10 out of 141 publications