The primary focus of the Wisconsin Alzheimer's Disease Research Center (ADRC) application is the study of preclinical Alzheimer's disease (AD), MCI, and early stage AD. The Minority Recruitment Satellite Program (MRSP) will establish a comprehensive and coordinated program of outreach education and recruitment activities to the African-American and Latino communities of Southeast Wisconsin. The goal of the MRSP program is to identify and eliminate the structural, attitudinal and social barriers to dementia diagnosis and research participation in the African-American and Latino communities. We will do this by implementing strategies demonstrated to be effective in achieving these goals by other successful Alzheimer's Disease Research Centers. Minority recruitment will be focused on two established and successful clinical and research programs. In Milwaukee, the MRSP Core will expand the existing minority outreach and education program established by the Wisconsin Alzheimer's Institute (WAI) and link this program to the Medical College of Wisconsin memory clinics directed by Dr. Piero Antuono. The Milwaukee program will replicate the """"""""supported"""""""" model of home-based assessment, care management and research developed by the Core Leader Dr. Dorothy Edwards for the Washington University ADRC in St. Louis. The Milwaukee program will also collaborate with the WAI clinic networks in Racine and Kenosha counties to identify and recruit potential minority participants who will be evaluated for the Clinical Core by Dr. Antuono and the ADRC research program. A second minority outreach, education and recruitment effort will be tailored to meet the needs and characteristics of minority residents of Dane and Rock counties. These participants will be evaluated by the ADRC Clinical Core in Madison. In this application, the MRSP is fully integrated into the Clinical and Education Cores to identify and resolve the barriers to research participation by African-Americans and Latinos. The MRSP will have the following aim:
Specific Aim 1 : Increase the enrollment, participation, and retention of African-American and Latino elders, asymptomatic middle-aged adult children and healthy controls in the ongoing research activities of the ADRC by providing culturally sensitive and appropriate community education, outreach, dementia screening, and referral to supportive health and social services.

Public Health Relevance

The major mission of the Minority Recruitment Satellite Program (MRSP) is to enhance enrollment and participation of underrepresented minorities and those belonging to low socioeconomic groups as well as residing in rural communities of Wisconsin. Alzheimer's disease is a common disorder in individuals of minority origin. The missions of the MRSP will significantly enhance the ability of Wisconsin ADRC to conduct research targeting underrepresented minorities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Specialized Center (P50)
Project #
5P50AG033514-05
Application #
8449649
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$20,713
Indirect Cost
$6,777
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Clark, Lindsay R; Koscik, Rebecca L; Allison, Samantha L et al. (2018) Hypertension and obesity moderate the relationship between ?-amyloid and cognitive decline in midlife. Alzheimers Dement :
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Martin, Stephen A; Souder, Dylan C; Miller, Karl N et al. (2018) GSK3? Regulates Brain Energy Metabolism. Cell Rep 23:1922-1931.e4
Swanson, Ashley; Wolf, Tovah; Sitzmann, Alli et al. (2018) Neuroinflammation in Alzheimer's disease: Pleiotropic roles for cytokines and neuronal pentraxins. Behav Brain Res 347:49-56
Gilmore-Bykovskyi, Andrea (2018) Commentary on Apathy as a Model for Investigating Behavioral and Psychological Symptoms in Dementia. J Am Geriatr Soc 66 Suppl 1:S13-S16
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Johnson, Sterling C; Koscik, Rebecca L; Jonaitis, Erin M et al. (2018) The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions. Alzheimers Dement (Amst) 10:130-142

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