Core Leader &Co-Leaders: S. ASTHANA;C.M. CARLSSON;P. ANTUONO CLINICAL CORE (CORE B) - PROJECT SUMMARY The primary objective of the Wisconsin Alzheimer's Disease Research Center's (ADRC) Clinical Core is to provide investigators access to well-characterized, diverse patient and control populations and high-quality, standardized clinical, cognitive, cerebrospinal fluid (CSF), serum/plasma, DNA, and neuroimaging data in order to facilitate translational Alzheimer's disease research in preclinical diagnosis and early intervention. To that end, the Core conducts comprehensive clinical evaluations in patients with mild cognitive impairment and mild Alzheimer's disease, cognitively normal older controls (>65 years), and middle-aged adults (45-65 years) with varying levels of dementia risk based on their family history of the disease. The Clinical Core team works closely with all Wisconsin ADRC Cores to facilitate the overall mission of the Center by participating in outreach and recruitment activities to diverse communities;conducting standardized clinical and cognitive assessments of Core participants;gathering ancillary aging-related cognitive and clinical data, including a detailed vascular risk assessment;collecting high-quality blood, CSF, and DNA biospecimens;coordinating biospecimen collection with neuroimaging;completing standardized data reporting in a timely manner; consenting Core participants for brain autopsy;facilitating cognitive testing and CSF collection within investigator-initiated studies;and ensuring timely availability of participants, data, and biospecimens to researchers both locally and nationally.
Specific Aim 1 : To continue to recruit and retain a pool of well- characterized middle-aged adults who are at risk for Alzheimer's disease, yet do not yet have symptoms of the disease, as well as a cohort of patients with mild cognitive impairment for regular clinical and cognitive evaluations and biomarker assessments (magnetic resonance imaging [MRI] and CSF and blood samples) to support translational research in preclinical dementia.
Specific Aim 2 : To continue to recruit and retain patients with mild late-onset AD and cognitively healthy older adults to undergo structured clinical and cognitive evaluations annually and to continue to encourage participation in biomarker assessments to support translational research in dementia and normal cognitive aging.
Specific Aim 3 : To integrate culturally-tailored outreach, education, and clinical services to diverse communities throughout Wisconsin in order to increase awareness of brain health and encourage long-term participation and advocacy for research within underrepresented minority communities.
Specific Aim 4 : To continue to obtain consent from Core participants for brain autopsy to support clinical-pathologic research and to collect CSF, blood, and DNA biospecimens for translational research on preclinical markers of dementia.
Specific Aim 5 : To continue to provide infrastructure, resources, and services to facilitate collaborative research in preclinical dementia, normal cognitive aging, and Alzheimer's disease locally and nationally. Through this work, Wisconsin ADRC investigators hope to identify early brain changes in asymptomatic people at risk for Alzheimer's disease in order to diagnose and treat the disease before any memory loss occurs.
|Willette, Auriel A; Johnson, Sterling C; Birdsill, Alex C et al. (2015) Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimers Dement 11:504-510.e1|
|Joshi, Gururaj; Gan, Kok Ann; Johnson, Delinda A et al. (2015) Increased Alzheimer's disease-like pathology in the APP/ PS1?E9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging 36:664-79|
|Engelman, Corinne D; Koscik, Rebecca L; Jonaitis, Erin M et al. (2014) Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention. Neurobiol Aging 35:1252-4|
|Kim, Hyunwoo J; Adluru, Nagesh; Bendlin, Barbara B et al. (2014) Canonical Correlation Analysis on Riemannian Manifolds and Its Applications. Comput Vis ECCV 8690:251-267|
|Hoy, Andrew R; Koay, Cheng Guan; Kecskemeti, Steven R et al. (2014) Optimization of a free water elimination two-compartment model for diffusion tensor imaging. Neuroimage 103:323-33|
|Okonkwo, Ozioma C; Oh, Jennifer M; Koscik, Rebecca et al. (2014) Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. J Int Neuropsychol Soc 20:422-33|
|Mielke, Michelle M; Haughey, Norman J; Bandaru, Veera V R et al. (2014) Cerebrospinal fluid sphingolipids, ?-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiol Aging 35:2486-94|
|Fischer, Barbara L; Gleason, Carey E; Gangnon, Ronald E et al. (2014) Declining cognition and falls: role of risky performance of everyday mobility activities. Phys Ther 94:355-62|
|Johnson, Sterling C; Christian, Bradley T; Okonkwo, Ozioma C et al. (2014) Amyloid burden and neural function in people at risk for Alzheimer's Disease. Neurobiol Aging 35:576-84|
|Okonkwo, Ozioma C; Schultz, Stephanie A; Oh, Jennifer M et al. (2014) Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology 83:1753-60|
Showing the most recent 10 out of 46 publications