Cardiovascular epidemiologic research historically has focused on men, because male sex is one of the major risk factors for CVD. Consequently, numerous diagnostic and treatment strategies for CVD in women have been extrapolated from results of studies conducted in men, and sex-specific factors largely have been ignored. It became apparent in the 1980s that the decrease in cardiovascular mortality in men was not accompanied by a similar decrease in women. One of the reasons for this difference might be sex-based disparities in cardiovascular care;women have been both under evaluated for CVD and under treated for modifiable risk factors for CVD. In addition, female-specific conditions, such as hypertensive disorders of pregnancy, menopause, and hormone use, might affect the onset of CVD, its clinical course, the efficacy of therapy, and, ultimately, prognosis. This proposal responds to RFA-OD-11-003 by identifying complications of hypertensive pregnancy disorders as a major biological sex difference that may influence the future cardiovascular and cognitive health of the affected women. Results of the proposed research may open new venues for the prevention, diagnosis, and treatment of CVD and cognitive impairment in women.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q (50))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Boeve, Bradley F; St Louis, Erik K; Kantarci, Kejal (2016) Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder. Brain 139:1005-7
Chen, Long; Ding, Mei-Lin; Wu, Fang et al. (2016) Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia: Role of 5,6,7,8-Tetrahydrobiopterin Oxidation and Endothelial Nitric Oxide Synthase Uncoupling. Hypertension 67:430-9
Gilani, Sarwat I; Weissgerber, Tracey L; Garovic, Vesna D et al. (2016) Preeclampsia and Extracellular Vesicles. Curr Hypertens Rep 18:68
Kling, Juliana M; Rose, Steven H; Kransdorf, Lisa N et al. (2016) Evaluation of sex- and gender-based medicine training in post-graduate medical education: a cross-sectional survey study. Biol Sex Differ 7:38
Kantarci, Kejal; Tosakulwong, Nirubol; Lesnick, Timothy G et al. (2016) Effects of hormone therapy on brain structure: A randomized controlled trial. Neurology 87:887-96
Miller, Virginia M; Kararigas, Georgios; Seeland, Ute et al. (2016) Integrating topics of sex and gender into medical curricula-lessons from the international community. Biol Sex Differ 7:44
Walton, Ronald L; Soto-Ortolaza, Alexandra I; Murray, Melissa E et al. (2016) TREM2 p.R47H substitution is not associated with dementia with Lewy bodies. Neurol Genet 2:e85
Miller, Virginia M; Lahr, Brian D; Bailey, Kent R et al. (2016) Longitudinal effects of menopausal hormone treatments on platelet characteristics and cell-derived microvesicles. Platelets 27:32-42
Ranadive, Sushant M; Harvey, Ronee E; Lahr, Brian D et al. (2016) Sympathetic Responsiveness is not Increased in Women with a History of Hypertensive Pregnancy. Am J Physiol Regul Integr Comp Physiol :ajpregu.00379.2016
Graff-Radford, Jonathan; Madhavan, Malini; Vemuri, Prashanthi et al. (2016) Atrial fibrillation, cognitive impairment, and neuroimaging. Alzheimers Dement 12:391-8

Showing the most recent 10 out of 89 publications